IGF binding proteins in cancer: mechanistic and clinical insights.

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Abstract

The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs) were originally characterized as passive reservoirs of circulating IGFs, but they are now understood to have many actions beyond their endocrine role in IGF transport. IGFBPs also function in the pericellular and intracellular compartments to regulate cell growth and survival - they interact with many proteins, in addition to their canonical ligands IGF-I and IGF-II. Intranuclear roles of IGFBPs in transcriptional regulation, induction of apoptosis and DNA damage repair point to their intimate involvement in tumour development, progression and resistance to treatment. Tissue or circulating IGFBPs might also be useful as prognostic biomarkers.

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Journal

Journal ID (iso-abbrev): Nat Rev Cancer

Title: Nature reviews. Cancer

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1474-1768

ISSN (Print): 1474-175X

Publication date (Electronic): May 2014

Volume: 14

Issue: 5

Affiliations

[1 ] Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia.

Article

Publisher Item ID: nrc3720

DOI: 10.1038/nrc3720

PubMed ID: 24722429

SO-VID: fbc68a63-8bf2-4b9c-9c7c-5bc3d614ad6f

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