Selective removal of lignin with sodium chlorite to improve the quality and antioxidant activity of xylo-oligosaccharides from lignocellulosic biomass

With the aid of DFT calculation, deep eutectic solvents can be designed more powerful for the pretreatment of lignocellulose and the production of biochemicals. As an emerging generation of green solvents, deep eutectic solvents (DESs) are promising for the pretreatment of lignocellulose and the production of biochemicals. However, not all DESs are effective for the cleavage of lignin–carbohydrate complexes (LCCs) in lignocellulose and the fractionation of lignin. In this study, we analyzed the nature of complex molecular interactions between choline chloride (ChCl) and glycerol in ChCl/glycerol (1 : 2) DES using density functional theory and the Kamlet–Taft solvatochromic method. The ChCl–glycerol DES exhibited weak competing interactions towards the linkages in the LCC network because the intramolecular hydrogen bonds (H-bonds) in ChCl–glycerol were constrained by mutually anionic H-bonds ([Cl(glycerol)] − ) and cationic H-bonds ([Ch(glycerol)] + ). Furthermore, because of the absence of active protons and acidic sites, the DES was unable to cleave ether bond linkages in the LCCs. Accordingly, we designed a three-constituent DES (3c-DES) by coordinating AlCl 3 ·6H 2 O in ChCl/glycerol DES based on an acidic multisite coordination theory. The competition of anionic H-bonds and unidentate aluminum ligands was synchronized to form supramolecular complexes, allowing the multisite bridging ligands to cleave both the H-bonds and ether bonds in LCCs. Consequently, the lignin fractionation efficiency was significantly improved from 3.61% to 95.46%, and the lignin purity reached 94 ± 0.45%.