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      Inflammatory markers in patients with hypertension

      Author(s): 1 , 1
      Publication date Created:
      Publication date (Print):
      Journal: British Journal of Hospital Medicine
      Publisher: Mark Allen Group

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          Abstract

          Hypertension is a chronic disease with high levels of morbidity and disability. Elevated blood pressure can lead to many complications and is the main risk factor for stroke, heart failure and nephropathy. Factors associated with hypertension and inflammatory response differ from those associated with vascular inflammation. The immune system plays a vital role in the pathophysiology of hypertension. Inflammation is particularly relevant in the progression of cardiovascular diseases, which has led to extensive research on inflammatory markers and indicators.

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          2020 International Society of Hypertension global hypertension practice guidelines

          Thomas Unger, Claudio Borghi, Fadi Joseph Charchar … (2020)
          Article 0 comments Cited 313 times – based on 0 reviews     Review now
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            Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis.

            S Chu, R Becker, P Berger … (2010)
            To determine whether an association exists between mean platelet volume (MPV) and acute myocardial infarction (AMI) and other cardiovascular events. Platelet activity is a major culprit in atherothrombotic events. MPV, which is widely available in clinical practice, is a potentially useful biomarker of platelet activity in the setting of cardiovascular disease. We performed a systematic review and meta-analysis investigating the association between MPV and AMI, all-cause mortality following myocardial infarction, and restenosis following coronary angioplasty. Results were pooled using random-effects modeling. Pooled results from 16 cross-sectional studies involving 2809 patients investigating the association of MPV and AMI indicated that MPV was significantly higher in those with AMI than those without AMI [mean difference 0.92 fL, 95% confidence interval (CI) 0.67-1.16, P < 0.001). In subgroup analyses, significant differences in MPV existed between subjects with AMI, subjects with stable coronary disease (P < 0.001), and stable controls (P < 0.001), but not vs. those with unstable angina (P = 0.24). Pooled results from three cohort studies involving 3184 patients evaluating the risk of death following AMI demonstrated that an elevated MPV increased the odds of death as compared with a normal MPV (11.5% vs. 7.1%, odds ratio 1.65, 95% CI 1.12-2.52, P = 0.012). Pooled results from five cohort studies involving 430 patients who underwent coronary angioplasty revealed that MPV was significantly higher in patients who developed restenosis than in those who did not develop restenosis (mean difference 0.98 fL, 95% CI 0.74-1.21, P < 0.001). Elevated MPV is associated with AMI, mortality following myocardial infarction, and restenosis following coronary angioplasty. These data suggest that MPV is a potentially useful prognostic biomarker in patients with cardiovascular disease. Whether the relationship is causal, and whether MPV should influence practice or guide therapy, remains unknown.
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              Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis.

              Arnoud Templeton, Olga Ace, Mairéad McNamara … (2014)
              Inflammation influences cancer development and progression. An elevated platelet to lymphocyte ratio (PLR), a marker of inflammation, has been linked to poor prognosis in several malignancies. Here, we quantify the prognostic impact of this biomarker.
              Article 0 comments Cited 169 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: British Journal of Hospital Medicine
                Abbreviated Title: Br J Hosp Med
                Publisher: Mark Allen Group
                ISSN (Print): 1750-8460
                ISSN (Electronic): 1759-7390
                Publication date Created: May 02 2023
                Publication date (Print): May 02 2023
                Volume: 84
                Issue: 5
                Pages: 1-8
                Affiliations
                [1 ]Department of General Practice, First Affiliated Hospital of Nanchang University, Nanchang, China
                Article
                DOI: 10.12968/hmed.2022.0531
                SO-VID: fb01711d-e5fb-4b80-8f24-6f3e67fb1a78
                Copyright © © 2023
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