Production of PHB Scaffolds Reinforced with HAp Through Electrospinning

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Abstract

Electrospinning, an economical technique, is widely used for biomedical scaffold fabrication, crucial in tissue and organ regeneration, particularly with biomaterials. Polymers, either pure or reinforced with ceramics, aid in cell proliferation and tissue formation. Polyhydroxybutyrate (PHB) is a promising biopolymer for tissue engineering, offering biocompatibility comparable to petroleum-derived polymers. Combining PHB with hydroxyapatite (HAp) enhances mechanical strength and osteoconductivity. This study aims to produce electrospun PHB microfibrous webs reinforced with HAp for scaffold fabrication. Morphological variations are analyzed through manipulation of electrospinning parameters. The study observed microfibrous webs with diameters ranging from 2 to 9 µm. Mechanical and microstructural evaluations demonstrate superior strength of PHB/HAp microfibrous webs compared to pure PHB, 1.23 MPa and 0.58 MPa respectively, demonstrating the efficacy of HAp reinforcement. These findings highlight the potential of PHB/HAp microfibrous webs in bone tissue engineering.

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Electrospinning: a fascinating fiber fabrication technique.

Nandana Bhardwaj, Subhas C. Kundu (2010)

With the emergence of nanotechnology, researchers become more interested in studying the unique properties of nanoscale materials. Electrospinning, an electrostatic fiber fabrication technique has evinced more interest and attention in recent years due to its versatility and potential for applications in diverse fields. The notable applications include in tissue engineering, biosensors, filtration, wound dressings, drug delivery, and enzyme immobilization. The nanoscale fibers are generated by the application of strong electric field on polymer solution or melt. The non-wovens nanofibrous mats produced by this technique mimics extracellular matrix components much closely as compared to the conventional techniques. The sub-micron range spun fibers produced by this process, offer various advantages like high surface area to volume ratio, tunable porosity and the ability to manipulate nanofiber composition in order to get desired properties and function. Over the years, more than 200 polymers have been electrospun for various applications and the number is still increasing gradually with time. With these in perspectives, we aim to present in this review, an overview of the electrospinning technique with its promising advantages and potential applications. We have discussed the electrospinning theory, spinnable polymers, parameters (solution and processing), which significantly affect the fiber morphology, solvent properties and melt electrospinning (alternative to solution electrospinning). Finally, we have focused on varied applications of electrospun fibers in different fields and concluded with the future prospects of this efficient technology. (c) 2010 Elsevier Inc. All rights reserved.