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      Genome Sequence of Streptomyces albulus PD-1, a Productive Strain for Epsilon-Poly-l-Lysine and Poly-l-Diaminopropionic Acid

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          Abstract

          Streptomyces albulus PD-1, a productive strain for epsilon-poly- l-lysine and poly- l-diaminopropionic acid, was isolated from soils. We present the genome sequence of S. albulus PD-1, which may provide abundant information regarding the production of epsilon-poly- l-lysine and poly- l-diaminopropionic acid.

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          NCBI Reference Sequences: current status, policy and new initiatives

          Kim D. Pruitt, Tatiana Tatusova, William Klimke … (2009)
          NCBI's Reference Sequence (RefSeq) database (http://www.ncbi.nlm.nih.gov/RefSeq/) is a curated non-redundant collection of sequences representing genomes, transcripts and proteins. RefSeq records integrate information from multiple sources and represent a current description of the sequence, the gene and sequence features. The database includes over 5300 organisms spanning prokaryotes, eukaryotes and viruses, with records for more than 5.5 × 106 proteins (RefSeq release 30). Feature annotation is applied by a combination of curation, collaboration, propagation from other sources and computation. We report here on the recent growth of the database, recent changes to feature annotations and record types for eukaryotic (primarily vertebrate) species and policies regarding species inclusion and genome annotation. In addition, we introduce RefSeqGene, a new initiative to support reporting variation data on a stable genomic coordinate system.
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            Antimicrobial action of epsilon-poly-L-lysine.

            SHOJI SHIMA, HIROYOSHI MATSUOKA, TOSHIRO IWAMOTO … (1984)
            The antimicrobial spectrum of epsilon-poly-L-lysine (n = 25-30, epsilon-PL) was investigated by comparison with alpha-poly-L-lysine (n = 50, alpha-PL). epsilon-PL showed antimicrobial activity against Gram-positive and -negative bacteria at concentrations of 1-8 micrograms/ml. alpha-PL was less active than epsilon-PL. A chain length of at least 10 L-lysine monomers was found to be optimum for antimicrobial activity. Chemical modification of the amino groups of epsilon-PL lowered its antibacterial activity. Studies on the mode of action of epsilon-PL suggest that absorption of epsilon-PL to the bacterial cell surface plays an important role in its antibacterial activity.
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              Microbial synthesis of poly(epsilon-lysine) and its various applications.

              Ming Shen, Xavier J Gallego Y van Seijen, Ing-Lung Shih (2006)
              This review article deals with the microbial synthesis, physiochemical properties, and potential applications of poly-epsilon-lysine (epsilon-PL), which is a naturally occurring biomaterial that is water soluble, biodegradable, edible and non-toxic toward humans and the environment. The potential applications of epsilon-PL as food preservatives, emulsifying agent, dietary agent, biodegradable fibers, highly water absorbable hydrogels, drug carriers, anticancer agent enhancer, biochip coatings in the fields of food, medicine, agriculture and electronics are also discussed in this review.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Genome Announc
                Journal ID (iso-abbrev): Genome Announc
                Journal ID (hwp): ga
                Journal ID (pmc): ga
                Journal ID (publisher-id): GA
                Title: Genome Announcements
                Publisher: American Society for Microbiology (1752 N St., N.W., Washington, DC )
                ISSN (Electronic): 2169-8287
                Publication date (Electronic): 17 April 2014
                Publication date Collection: Mar-Apr 2014
                Volume: 2
                Issue: 2
                Electronic Location Identifier: e00297-14
                Affiliations
                [a ]State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing, China
                [b ]College of Food Science and Light Industry, Nanjing University of Technology, Nanjing, China
                Author notes
                Address correspondence to Hong Xu, xuh@ 123456njut.edu.cn .

                Z.X. and J.X. had equal contributions to this work.

                Article
                Publisher ID: genomeA00297-14
                DOI: 10.1128/genomeA.00297-14
                PMC ID: 3990750
                PubMed ID: 24744334
                SO-VID: fa5f0995-41b7-46a7-b19b-443a15f7b4f4
                Copyright © Copyright © 2014 Xu et al.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.

                History
                Date received : 23 March 2014
                Date accepted : 25 March 2014
                Page count
                Pages: 2
                Categories
                Subject: Prokaryotes
                Custom metadata
                cover-date March/April 2014
                access-type free

                ScienceOpen disciplines: Genetics
                Data availability:
                ScienceOpen disciplines: Genetics

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