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Bivalirudin during primary PCI in acute myocardial infarction.
Gregg W Stone
1 ,
Bernhard Witzenbichler ,
Giulio Guagliumi ,
Jan Z Peruga ,
Bruce R Brodie ,
Dariusz Dudek ,
Ran Kornowski ,
Franz Hartmann ,
Bernard J Gersh ,
Stuart J Pocock ,
George Dangas ,
S Chiu Wong ,
Ajay J Kirtane ,
Helen Parise ,
Roxana Mehran
May 22 2008
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Abstract
Treatment with the direct thrombin inhibitor bivalirudin, as compared with heparin plus glycoprotein IIb/IIIa inhibitors, results in similar suppression of ischemia while reducing hemorrhagic complications in patients with stable angina and non-ST-segment elevation acute coronary syndromes who are undergoing percutaneous coronary intervention (PCI). The safety and efficacy of bivalirudin in high-risk patients are unknown.