Poly(ADP-ribose): novel functions for an old molecule.

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Abstract

The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique post-translational modification. It regulates not only cell survival and cell-death programmes, but also an increasing number of other biological functions with which novel members of the PARP family have been associated. These functions include transcriptional regulation, telomere cohesion and mitotic spindle formation during cell division, intracellular trafficking and energy metabolism.

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Journal

Journal ID (iso-abbrev): Nat Rev Mol Cell Biol

Title: Nature reviews. Molecular cell biology

Publisher: Springer Science and Business Media LLC

ISSN: 1471-0072

ISSN (Print): 1471-0072

Publication date (Electronic): Jul 2006

Volume: 7

Issue: 7

Affiliations

[1 ] Département Intégrité du Génome de l'UMR 7175, Centre National de la Recherche Scientifique, Ecole Supérieure de Biotechnologie de Strasbourg, Boulevard S. Brant, BP 10413, F-67412 Illkirch Cedex, France. schreiber@esbs.u-strasbg.fr

Article

Publisher Item ID: nrm1963

DOI: 10.1038/nrm1963

PubMed ID: 16829982

SO-VID: f8f2f9a1-8235-43c9-bd39-819aa67ab6ed

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