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      Role of socio-economic research in developing, delivering and scaling new crop varieties: the case of staple crop biofortification

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          Abstract

          The CGIAR biofortification program, HarvestPlus, was founded with the aim of improving the quality of diets through micronutrient-dense varieties of staple food crops. Implemented in four phases – discovery, development, delivery and scaling – the program was designed to be interdisciplinary, with plant breeding R&D supported by nutrition and socio-economic research. This paper explains the need, use and usefulness of socio-economic research in each phase of the program. Ex ante and ex post benefit-cost analyses facilitated fundraising for initial biofortification R&D and implementation in each subsequent phase, as well as encouraged other public, private, and civil society and non-governmental organizations to take on and mainstream biofortification in their crop R&D, policies, and programs. Socio-economics research helped guide plant breeding by identifying priority micronutrient- crop- geography combinations for maximum impact. Health impacts of biofortification could be projected both by using empirical results obtained through randomized controlled bioefficacy trials conducted by nutritionists, and through farmer-adoption models estimating impact at scale. Farmer and consumer surveys and monitoring systems provided the underlying information for estimating farmer adoption models and helped understand input/output markets, farmer and consumer preferences, and additional opportunities and challenges –all of which informed crop breeding and delivery activities, while building the knowledge base for catalyzing the scaling of biofortification.

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          Most cited references77

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          Evidence of decreasing mineral density in wheat grain over the last 160 years.

          Wheat is an important source of minerals such as iron, zinc, copper and magnesium in the UK diet. The dietary intake of these nutrients has fallen in recent years because of a combination of reduced energy requirements associated with sedentary lifestyles and changes in dietary patterns associated with lower micronutrient density in the diet. Recent publications using data from food composition tables indicate a downward trend in the mineral content of foods and it has been suggested that intensive farming practices may result in soil depletion of minerals. The aim of our study was to evaluate changes in the mineral concentration of wheat using a robust approach to establish whether trends are due to plant factors (e.g. cultivar, yield) or changes in soil nutrient concentration. The mineral concentration of archived wheat grain and soil samples from the Broadbalk Wheat Experiment (established in 1843 at Rothamsted, UK) was determined and trends over time examined in relation to cultivar, yield, and harvest index. The concentrations of zinc, iron, copper and magnesium remained stable between 1845 and the mid 1960s, but since then have decreased significantly, which coincided with the introduction of semi-dwarf, high-yielding cultivars. In comparison, the concentrations in soil have either increased or remained stable. Similarly decreasing trends were observed in different treatments receiving no fertilizers, inorganic fertilizers or organic manure. Multiple regression analysis showed that both increasing yield and harvest index were highly significant factors that explained the downward trend in grain mineral concentration.
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            World Development Report 1993

            (1993)
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              Introduction of β-carotene-rich orange sweet potato in rural Uganda resulted in increased vitamin A intakes among children and women and improved vitamin A status among children.

              Vitamin A deficiency (VAD) persists in Uganda and the consumption of β-carotene-rich orange sweet potato (OSP) may help to alleviate it. Two large-scale, 2-y intervention programs were implemented among Ugandan farmer households to promote the production and consumption of OSP. The programs differed in their inputs during year 2, with one being more intensive (IP) and the other being reduced (RP). A randomized, controlled effectiveness study compared the impact of the IP and RP with a control on OSP and vitamin A intakes among children aged 6-35 mo (n = 265) and 3-5 y (n = 578), and women (n = 573), and IP compared with control on vitamin A status of 3- to 5-y-old children (n = 891) and women (n = 939) with serum retinol 30 percentage points) and women (>25 percentage points) (P < 0.01), with no differences between the IP and RP groups of children (P = 0.75) or women (P = 0.17). There was a 9.5 percentage point reduction in prevalence of serum retinol <1.05 μmol/L for children with complete data on confounding factors (n = 396; P < 0.05). At follow-up, vitamin A intake from OSP was positively associated with vitamin A status (P < 0.05). Introduction of OSP to Ugandan farming households increased vitamin A intakes among children and women and was associated with improved vitamin A status among children.
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                Author and article information

                Contributors
                Journal
                Front Plant Sci
                Front Plant Sci
                Front. Plant Sci.
                Frontiers in Plant Science
                Frontiers Media S.A.
                1664-462X
                03 July 2023
                2023
                : 14
                : 1099496
                Affiliations
                [1] 1 Global Human Development Program, Edmund A. Walsh School of Foreign Service, Georgetown University , Washington, DC, United States
                [2] 2 International Food Policy Research Institute, HarvestPlus and Micronutrient Forum , Los Banos, Philippines
                Author notes

                Edited by: Marta Wilton Vasconcelos, Catholic University of Portugal, Portugal

                Reviewed by: Edward Joy, University of London, United Kingdom; Poonam Yadav, Institute of Environment and Sustainable Development, Banaras Hindu University, India; Bálint Balázs, Environmental Social Sciences Research Group, Hungary

                *Correspondence: Ekin Birol, eb1302@ 123456georgetown.edu
                Article
                10.3389/fpls.2023.1099496
                10350902
                f815d0a3-c86f-48e5-a19e-bb37f5067031
                Copyright © 2023 Birol and Bouis

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 15 November 2022
                : 04 April 2023
                Page count
                Figures: 9, Tables: 1, Equations: 0, References: 79, Pages: 17, Words: 10453
                Funding
                We are grateful to all our donors, a complete list of which can be found on the HarvestPlus website. We are especially grateful to the Bill and Melinda Gates Foundation, FCDO, BMZ, EC and donors to the CGIAR research program on Agriculture for Nutrition and Health (A4NH), and to our supportive and inquisitive program officers in each, as well as to HarvestPlus board, without whose many very valid questions and requests this socio-economic research portfolio could not have reached its full potential.
                Categories
                Plant Science
                Review

                Plant science & Botany
                biofortification,socio-economic research,cost-effectiveness,impact evaluation,consumer acceptance,farmer adoption,monitoring,program evaluation and learning

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