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      Magnetite loaded Polypeptide-PLGA multifunctional microbubbles for dual-mode US/MR imaging.

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          Abstract

          Magnetite loaded Polypeptide-PLGA multifunctional microbubbles (Fe3O4 /Polypeptide-PLGA MMBs) that show superparamagnetic properties were prepared by a modified double emulsion method and employed as imaging agent for dual-mode Ultrasound/Magnetic resonance (US/MR) imaging of prostatic cancer. The successful synthesis of MMBs was determined by Fourier Transform Infrared Spectrometer (FTIR), X-ray diffraction (XRD), Transmission Electron Microscope (TEM), Scanning Electron Microscope (SEM), Atomic Absorption Spectroscopy (AAS) and vibrating sample magnetometer (VSM). The as-prepared MMBs had a diameter of 700 nm and were quite safe as confirmed by MTT assays. Prussian Blue Staining showed that targeted Fe3O4 /Polypeptide-PLGA MMBs enhanced the cellular uptake efficiency. In cell attachment study, adherence of MMBs was significantly higher to LNCaP cells compared with negative control PC3 cells. The in vitro results demonstrated that these MMBs could enhance both US and MR imaging of prostatic cancer.

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          Author and article information

          Journal
          Contrast Media Mol Imaging
          Contrast media & molecular imaging
          Wiley
          1555-4317
          1555-4309
          December 10 2015
          : 11
          : 2
          Affiliations
          [1 ] State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, People's Republic of China.
          [2 ] Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, People's Republic of China.
          [3 ] Key Lab of Advanced Technologies of Materials (Ministry of Education of China), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, People's Republic of China.
          Article
          10.1002/cmmi.1675
          26647349
          f76accae-0d1e-426e-8d08-c549f00c8d61
          History

          polypeptide targeting,iron oxide,microbubbles,ultrasound and magnetic resonance imaging

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