Leolin Katsidzira:
ORCID: http://orcid.org/0000-0003-4815-5207
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Writing – original draftRole: Writing – review
& editing
Anna Vorster: Role: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – review &
editing
Innocent T. Gangaidzo: Role: ConceptualizationRole: Data curationRole: Writing – review & editing
Rudo Makunike-Mutasa: Role: Data curationRole: InvestigationRole: Writing – review & editing
Dhiren Govender: Role: InvestigationRole: MethodologyRole: ResourcesRole: Writing – review & editing
Simbarashe Rusakaniko: Role: Formal analysisRole: Writing – review & editing
Sandie Thomson: Role: Formal analysisRole: Writing – review & editing
Jonathan A. Matenga: Role: ConceptualizationRole: Funding acquisitionRole: Writing – review & editing
Raj Ramesar: Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Alvaro Galli: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
24
October
2019
Publication date Collection: 2019
Volume: 14
Issue: 10
Electronic Location Identifier: e0224023
Affiliations
[1
]
Department of Medicine, College of Health Sciences, University of Zimbabwe, Harare,
Zimbabwe
[2
]
MRC/UCT Research Unit for Genomic and Precision Medicine, Division of Human Genetics,
Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences,
University of Cape Town, Cape Town, South Africa
[3
]
Central Analytical Facility (CAF), DNA Sequencing Unit, Stellenbosch University, Stellenbosch,
South Africa
[4
]
Department of Histopathology, College of Health Sciences, University of Zimbabwe,
Harare, Zimbabwe
[5
]
Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town,
and National Health Laboratory Service Groote Schuur hospital, Cape Town, South Africa
[6
]
Department of Community Medicine, College of Health Sciences, University of Zimbabwe,
Harare, Zimbabwe
[7
]
Division of Gastroenterology, Department of Medicine, University of Cape Town, Cape
Town, Groote Schuur Hospital, Cape Town, South Africa
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-19-03920
DOI: 10.1371/journal.pone.0224023
PMC ID: 6812839
PubMed ID: 31647837
SO-VID: f70a0e1f-264f-48a6-81c4-e12ba4ec531f
Copyright © © 2019 Katsidzira et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100004440, Wellcome Trust;
Award ID: WT087537MA
Funded by: Gastro Foundation of sub-Saharan Africa
Award Recipient
:
ORCID: http://orcid.org/0000-0003-4815-5207
Leolin Katsidzira
Funded by: Medical Research Council of South Africa
Award Recipient
:
Raj Ramesar
This work was supported by the Wellcome Trust (Southern African Consortium for Research
Excellence initiative, WT087537MA) to LK; the Gastro Foundation of Sub-Saharan Africa
to LK and the Medical Research Council of South Africa to RR. The funders had no role
in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Colorectal Cancer
Subject:
Medicine and Health Sciences
Subject:
Clinical Genetics
Subject:
Genetic Diseases
Subject:
Autosomal Dominant Diseases
Subject:
Hereditary Nonpolyposis Colorectal Cancer
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
DNA
Subject:
DNA repair
Subject:
Mismatch Repair
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
DNA
Subject:
DNA repair
Subject:
Mismatch Repair
Subject:
People and Places
Subject:
Geographical Locations
Subject:
Africa
Subject:
Biology and life sciences
Subject:
Molecular biology
Subject:
Molecular biology techniques
Subject:
Sequencing techniques
Subject:
DNA sequencing
Subject:
Next-Generation Sequencing
Subject:
Research and analysis methods
Subject:
Molecular biology techniques
Subject:
Sequencing techniques
Subject:
DNA sequencing
Subject:
Next-Generation Sequencing
Subject:
Biology and Life Sciences
Subject:
Computational Biology
Subject:
Genome Analysis
Subject:
Transcriptome Analysis
Subject:
Next-Generation Sequencing
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Genome Analysis
Subject:
Transcriptome Analysis
Subject:
Next-Generation Sequencing
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Gastrointestinal Tract
Subject:
Rectum
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Gastrointestinal Tract
Subject:
Rectum
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Gastrointestinal Tract
Subject:
Colon
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Gastrointestinal Tract
Subject:
Colon
Subject:
People and Places
Subject:
Geographical Locations
Subject:
Africa
Subject:
Zimbabwe
