Associations between serotonin transporter gene (SLC6A4) methylation and clinical characteristics and cortical thickness in children with ADHD.

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Abstract

Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Additionally, environmental factors such as perinatal stress and early adversities contribute to the occurrence and severity of ADHD. Recently, DNA methylation has emerged as a mechanism that potentially mediates gene-environmental interaction effects in the aetiology and phenomenology of psychiatric disorders. Here, we investigated whether serotonin transporter gene (SLC6A4) methylation patterns were associated with clinical characteristics and regional cortical thickness in children with ADHD.

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Author and article information

Journal

Journal ID (iso-abbrev): Psychol Med

Title: Psychological medicine

Publisher: Cambridge University Press (CUP)

ISSN (Electronic): 1469-8978

ISSN (Print): 0033-2917

Publication date (Electronic): Oct 2015

Volume: 45

Issue: 14

Affiliations

[1 ] Department of Psychiatry,Seoul National Hospital,Seoul,Republic of Korea.

[2 ] Department of Biomedical Engineering,Hanyang University,Seoul,Republic of Korea.

[3 ] Division of Child and Adolescent Psychiatry,Department of Psychiatry,Seoul National University College of Medicine,Seoul,Republic of Korea.

[4 ] Lab Genomics Clinical Research Institute,Seoul,Republic of Korea.

[5 ] Department of Psychiatry,College of Medicine,Chung Ang University,Seoul,Republic of Korea.

[6 ] Uimyung Research Institute for Neuroscience,Sahmyook University,Seoul,Republic of Korea.

Article

Publisher Item ID: S003329171500094X

DOI: 10.1017/S003329171500094X

PubMed ID: 26017091

SO-VID: f668176e-26fb-49ad-b934-0a69b458d4f6

History

Keywords: Attention deficit hyperactivity disorder,brain imaging,gene–environment interaction,neuropsychology

Data availability:

Keywords: Attention deficit hyperactivity disorder, brain imaging, gene–environment interaction, neuropsychology

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