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      Two-dimensional shear wave elastography for screening varices in Asian patients with primary biliary cholangitis.

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          Abstract

          Objectives: The presence of varices affects the survival of patients with primary biliary cholangitis (PBC). The aim of this study is to assess the criteria based on liver stiffness (LS) measured by two-dimensional shear wave elastography (2D-SWE) and platelet count (PLT), and recently published noninvasive models for triaging PBC patients.Methods: 231 patients with PBC who underwent EGD and 2D-SWE examination were enrolled. Areas under the receiver-operating characteristic curve (AUROC) were used to assess the performance of 2D-SWE for predicting all-size varices and high-risk varices. All-size varices and high-risk varices miss rate < 10% and <5%, respectively, were acceptable for screening varices.Results: The AUROCs of LS for predicting all-size varices and high-risk varices were 0.87 (95%CI: 0.82-0.91) and 0.84 (95%CI: 0.74-0.86), respectively. LS <25 kPa and PLT >110 × 109/L spared 46.3% EGD screening, with 3.7% high-risk varices miss rate and 8.4% all-size varices miss rate. One hundred and sixteen (50.2%) patients met the Newcastle varices in PBC score (cutoff, 0.5), with 4.3% high-risk varices miss rate and 11.2% all-size varices miss rate.Conclusion: The criteria based on LS and PLT are useful for triaging PBC patients. LS <25 kPa and PLT >110 × 109/L could be the optimal criteria for screening varices.

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          Author and article information

          Journal
          Expert Rev Gastroenterol Hepatol
          Expert review of gastroenterology & hepatology
          Informa UK Limited
          1747-4132
          1747-4124
          Aug 2021
          : 15
          : 8
          Affiliations
          [1 ] Sichuan University-University of Oxford Huaxi Joint for Gastrointestinal Cancer Centre, Sichuan University, Chengdu, Sichuan, China.
          [2 ] Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
          [3 ] Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
          Article
          10.1080/17474124.2021.1884071
          33513034
          f65c2723-ac9b-4608-8d03-a7b98ae95db6
          History

          ultrasound,Esophageal Varices,liver stiffness,primary biliary cholangitis,2D-SWE Elastography

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