Calcitriol and enamel matrix derivative differentially regulated cemento-induction and mineralization in human periodontal ligament-derived cells.

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Abstract

Alveolar bone and cementum share many biological and developmental similarities. The mineralizing effect of calcitriol has been previously reported. Yet, its cemento-inductivity has not been confirmed. This study evaluated the potential cemento-inductivity effect of calcitriol and enamel matrix derivative (EMD) on human periodontal ligament-derived cells (hPDLCs).

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Author and article information

Journal

Journal ID (iso-abbrev): J Periodontol

Title: Journal of periodontology

Publisher: Wiley

ISSN (Electronic): 1943-3670

ISSN (Print): 0022-3492

Publication date (Electronic): Oct 2022

Volume: 93

Issue: 10

Affiliations

[1 ] Department of Periodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

[2 ] Graduate Institute of Dental and Craniofacial Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

[3 ] Valley Consortium for Medical Education, Family Medicine Residency, University of California Davis, Modesto, CA, USA.

[4 ] Department of General Dentistry, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

[5 ] School of Dentistry, College of Oral medicine, Taipei Medical University, Taipei, Taiwan.

[6 ] Department of Nephrology, Clinical Poison Center, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.

[7 ] Department of Prosthodontics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

[8 ] Center for Tissue Engineering, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

[9 ] Department of Life Sciences, National Central University, Taoyuan, Taiwan.

Article

DOI: 10.1002/JPER.21-0435

PubMed ID: 34837709

SO-VID: f5f1f31f-b794-4e75-943b-bed88a98549d

History

Keywords: cementum,gene expression,periodontal regeneration

Data availability:

Keywords: cementum, gene expression, periodontal regeneration

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