Xueqiang Zhu: Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
SupervisionRole: ValidationRole: VisualizationRole: Writing – review & editing
Xing Luo: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: SoftwareRole:
ValidationRole: Writing – review & editing
Gang Feng: Role: Data curationRole: ValidationRole: Writing – original draft
Hui Huang: Role: InvestigationRole: MethodologyRole: Writing – original draft
Yangke He: Role: MethodologyRole: Writing – review & editing
Wen Ma: Role: ConceptualizationRole: Formal analysisRole: MethodologyRole: SupervisionRole:
ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review
& editing
Changqing Zhang:
ORCID: http://orcid.org/0000-0002-8311-8607
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: MethodologyRole:
SoftwareRole: Writing – original draft
Ming Zeng: Role: MethodologyRole: Supervision
Hao Liu: Role: Formal analysisRole: Funding acquisitionRole: MethodologyRole: SoftwareRole:
ValidationRole: Writing – review & editing
Hiromu Suzuki: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
4
February
2019
Publication date Collection: 2019
Volume: 14
Issue: 2
Electronic Location Identifier: e0207341
Affiliations
[1
]
Cancer Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital,
School of Medicine, University of Electronic Science and Technology of China, Chengdu,
China
[2
]
Division of Thoracic Surgery, Department of Surgery, Sichuan Academy of Medical Sciences
& Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic
Science and Technology of China, Chengdu, China
[3
]
Department of Tumor Center, Gansu Provincial People's Hospital, Lanzhou, China
Sapporo Ika Daigaku, JAPAN
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-18-16980
DOI: 10.1371/journal.pone.0207341
PMC ID: 6361429
PubMed ID: 30716092
SO-VID: f520e3b6-d3e5-4c5d-b8ab-94bb3c3cab6a
Copyright © © 2019 Zhu et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/501100004829, Department of Science and Technology of Sichuan Province;
Award ID: 30504010336
Award Recipient
:
Ming Zeng
Funded by: Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital
Award ID: 30305031017P
Award Recipient
:
Ming Zeng
This work was supported by Department of Science and Technology of Sichuan Province,
30504010336, Ming Zeng; Sichuan Academy of Medical Sciences & Sichuan Provincial People’s
Hospital, 30305031017P, Ming Zeng. The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Chromosome biology
Subject:
Chromatin
Subject:
Chromatin modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Epigenetics
Subject:
Chromatin
Subject:
Chromatin modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Gene expression
Subject:
Chromatin
Subject:
Chromatin modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
DNA
Subject:
DNA modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
DNA
Subject:
DNA modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Epigenetics
Subject:
DNA modification
Subject:
DNA methylation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Gene expression
Subject:
DNA modification
Subject:
DNA methylation
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Carcinomas
Subject:
Squamous Cell Carcinomas
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Histology
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Histology
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
Subject:
Radiation Therapy
Subject:
Medicine and Health Sciences
Subject:
Clinical Medicine
Subject:
Clinical Oncology
Subject:
Radiation Therapy
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Clinical Oncology
Subject:
Radiation Therapy
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Basic Cancer Research
Subject:
Cancer Genomics
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Genomic Medicine
Subject:
Cancer Genomics
Subject:
Research and Analysis Methods
Subject:
Mathematical and Statistical Techniques
Subject:
Statistical Methods
Subject:
Multivariate Analysis
Subject:
Physical Sciences
Subject:
Mathematics
Subject:
Statistics
Subject:
Statistical Methods
Subject:
Multivariate Analysis
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Gastrointestinal Tumors
Subject:
Esophageal Cancer
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
