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      Bibliometric analysis of top 100 cited articles in nonalcoholic fatty liver disease research

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          Abstract

          AIM

          To identify and assess the research situation of top 100 cited articles in nonalcoholic fatty liver disease (NAFLD).

          METHODS

          The global scientific research articles in the Science Citation Index-Expanded relevant to NAFLD were retrieved and listed according to their citation times from the most to the least. The 100 most frequently cited original articles were selected to systematically evaluate their bibliometric parameters including times cited, publication year, journals, subject categories, and the highly related concepts of NAFLD, which reflected the history and current situation, publication distribution of leading countries and institutes as well as the research hotspots of NAFLD.

          RESULTS

          Top 100 cited articles in NAFLD were published from 1965 to 2015 with a citation ranging of 227 to 2151 times since publication, in which the United States was the most predominant country and Mayo Clin was the most productive institution. The majority of the top 100 cited articles were concentrated in SCI subject category of Gastroenterology and Hepatology. Hepatology and Gastroenterology is the top journal that published over half 100 top-cited articles. The significant peak of top cited articles present in the first half of the 2000s while the highest mean number of citation presents in first half of the 1980s. In addition, concepts related to pathology characteristics, epidemiology and medicalization, metabolic syndrome and its combination of symptoms including insulin resistance, biomarkers of lipid metabolism and obesity are listed as the highly related concepts.

          CONCLUSION

          The 100 top-cited articles marked with the leading countries, institutions, journals, hotspots and development trend in NAFLD field that could provide the foundation for further investigations.

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          Most cited references22

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          World Gastroenterology Organisation global guidelines: Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

          Douglas LaBrecque, Zaigham Abbas, Frank A. Anania … (2014)
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            Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis.

            S Wang, Nikul Soni, Gongshe Yang … (2011)
            Accumulation of cytoplasmic triacylglycerol (TG) underlies hepatic steatosis, a major cause of cirrhosis. The pathways of cytoplasmic TG metabolism are not well known in hepatocytes, but evidence suggests an important role in lipolysis for adipose triglyceride lipase (ATGL). We created mice with liver-specific inactivation of Pnpla2, the ATGL gene. These ATGLLKO mice had severe progressive periportal macrovesicular and pericentral microvesicular hepatic steatosis (73, 150, and 226 μmol TG/g liver at 4, 8, and 12 months, respectively). However, plasma levels of glucose, TG, and cholesterol were similar to those of controls. Fasting 3-hydroxybutyrate level was normal, but in thin sections of liver, beta oxidation of palmitate was decreased by one-third in ATGLLKO mice compared with controls. Tests of very low-density lipoprotein production, glucose, and insulin tolerance and gluconeogenesis from pyruvate were normal. Plasma alanine aminotransferase levels were elevated in ATGLLKO mice, but histological estimates of inflammation and fibrosis and messenger RNA (mRNA) levels of tumor necrosis factor-α and interleukin-6 were similar to or lower than those in controls. ATGLLKO cholangiocytes also showed cytoplasmic lipid droplets, demonstrating that ATGL is also a major lipase in cholangiocytes. There was a 50-fold reduction of hepatic diacylglycerol acyltransferase 2 mRNA level and a 2.7-fold increase of lipolysosomes in hepatocytes (P < 0.001), suggesting reduced TG synthesis and increased lysosomal degradation of TG as potential compensatory mechanisms. Compared with the hepatic steatosis of obesity and diabetes, steatosis in ATGL deficiency is well tolerated metabolically. ATGLLKO mice will be useful for studying the pathophysiology of hepatic steatosis. Copyright © 2011 American Association for the Study of Liver Diseases.
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              Citation classics in anesthetic journals.

              C Kindler, Anja Baltussen (2004)
              The number of citations an article receives after its publication reflects its recognition in the scientific community. In the present study, therefore, we identified and examined the characteristics of the top 100 most frequently cited articles published in anesthetic journals. These articles were identified using the database of the Science Citation Index Expanded (SCI-EXPANDED, 1945 to present) and the Web of SCIENCE(R). The most-cited article received 707 citations and the least cited article received 197 citations, with a mean of 283 citations per article. These citation classics were published between 1954 and 1997 in 5 high-impact anesthetic journals, led by Anesthesiology (73 articles) followed by Anesthesia & Analgesia (10), British Journal of Anesthesia (10), Anesthesia (6), and Acta Anaesthesiologica Scandinavica (2). Seventy-eight articles were original publications, 22 were review articles, and one was an editorial. They originated from nine countries, with the United States contributing 70 articles. Within the United States, California leads the list of citation classics with 25 articles. Twenty-nine persons authored two or more of the top-cited articles. The main topics covered by the top-cited articles are pharmacology, volatile anesthetics, circulation, regional anesthesia, and lung physiology. This analysis of citation rates allows for the recognition of seminal advances in anesthesia and gives a historic perspective on the scientific progress of this specialty. We performed a citation analysis to identify important contributions and contributors to the anesthetic literature. These classic articles have influenced many people and have brought to our attention the many important advances in anesthesia made during the last 50 yr.
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                Author and article information

                Journal
                Journal ID (nlm-ta): World J Hepatol
                Journal ID (publisher-id): WJH
                Title: World Journal of Hepatology
                Publisher: Baishideng Publishing Group Inc
                ISSN (Electronic): 1948-5182
                Publication date (Print): 28 November 2016
                Publication date (Electronic): 28 November 2016
                Volume: 8
                Issue: 33
                Pages: 1478-1488
                Affiliations
                Tong-Shuo Zhang, Hua-Lei Qin, Tong Wang, Hai-Tao Li, Hai Li, Shi-Hai Xia, Xiao-Hui Xiang, Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of People’s Armed Police Force, Tianjin 300162, China
                Author notes

                Author contributions: Zhang TS, Qin HL, Wang T, Li HT, Li H and Xiang XH prepared the manuscript; Xia SH and Xiang XH contributed to the conception of this work, revised and approved the manuscript.

                Supported by The National Natural Science Foundation of China, No. 81173393; the Natural Science Foundation of Tianjin City, No. 12JCZDJC25500; and the Innovation Team Program from Logistics University of People’s Armed Police Force , No. WHTD201310.

                Correspondence to: Dr. Xiao-Hui Xiang, Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital, Logistics University of People’s Armed Police Force, 220 Chenglin Road, Hedong District, Tianjin 300162, China. xiaohuixiang@ 123456163.com

                Telephone: +86-22-60578765 Fax: +86-22-24370605

                Article
                Other ID: jWJH.v8.i33.pg1478
                DOI: 10.4254/wjh.v8.i33.1478
                PMC ID: 5124720
                PubMed ID: 27957247
                SO-VID: f4a64462-b783-4895-bc61-7b32d15a2815
                Copyright © ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
                License:

                This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

                History
                Date received : 10 June 2016
                Date revision received : 10 August 2016
                Date accepted : 21 September 2016
                Categories
                Subject: Systematic Reviews

                Keywords: bibliometrics,top-cited articles,metabolic syndrome,prevalence,medicalization,nonalcoholic fatty liver disease
                Data availability:
                Keywords: bibliometrics, top-cited articles, metabolic syndrome, prevalence, medicalization, nonalcoholic fatty liver disease

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