TCR Clonality and Genomic Instability Signatures as Prognostic Biomarkers in High Grade Serous Ovarian Cancer.

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Abstract

Immune infiltration is a prognostic factor in high-grade serous ovarian carcinoma (HGSC) but immunotherapy efficacy is disappointing. Genomic instability is now used to guide the therapeutic value of PARP inhibitors. We aimed to investigate exome-derived parameters to assess the tumor microenvironment according to genomic instability profile.

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Journal

Journal ID (iso-abbrev): Cancers (Basel)

Title: Cancers

Publisher: MDPI AG

ISSN: 2072-6694

ISSN (Print): 2072-6694

Publication date (Electronic): Aug 31 2021

Volume: 13

Issue: 17

Affiliations

[1 ] Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-UNICANCER, 1 rue du Professeur Marion, 21000 Dijon, France.

[2 ] Unité Mixte de Recherche (UMR) INSERM 1231, 7 Boulevard Jeanne d'Arc, 21000 Dijon, France.

[3 ] Institut de Chimie Moléculaire Université de Bourgogne (ICMUB) UMR CNRS 6302, 21000 Dijon, France.

[4 ] Department of Biology and Pathology of Tumors, Georges François Leclerc Cancer Center-UNICANCER, 1 rue du Professeur Marion, 21000 Dijon, France.

[5 ] Department of Medical Oncology, Georges François Leclerc Cancer Center-UNICANCER, 1 rue du Professeur Marion, 21000 Dijon, France.

[6 ] Laboratoire RESHAPE University Claude Bernard Lyon I, Department of Medical Oncology, Léon-Bérard Center, 28 rue Laennec, 69008 Lyon, France.

[7 ] Maison de l'université Esplanade Erasme, University of Burgundy-Franche Comté, 21000 Dijon, France.

[8 ] Genomic and Immunotherapy Medical Institute, Dijon University Hospital, 14 rue Paul Gaffarel, 21000 Dijon, France.

Article

Publisher Item ID: cancers13174394

DOI: 10.3390/cancers13174394

PMC ID: 8430641

PubMed ID: 34503204

SO-VID: f3ff24a4-6a00-4136-a52a-8d49e527fa4a

History

Keywords: biomarkers,prognostic,HGSC,HRD,TCR clonality

Data availability:

Keywords: biomarkers, prognostic, HGSC, HRD, TCR clonality

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