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      Case Report: Energy- and Nutrient-Dense Formula for Growth Faltering: A Report of Two Cases From India

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          Abstract

          Infants hospitalized for critical illnesses are at a high risk of undernutrition because of increased nutrient requirements (due to increased metabolism) and decreased nutrient intake (due to disease-related problems such as anorexia or feeding difficulties). This can result in a slowing down of their normal growth, referred to as “growth faltering.” Appropriate nutritional management of these infants is extremely important to avoid long-term adverse outcomes. Administration of energy- and nutrient-dense formula (ENDF; 100 kcal energy and 2.6 g protein per 100 mL, with added micronutrients) can be an effective means of increasing the nutrient and energy intake of these children. Despite the high prevalence of undernutrition and growth faltering among pediatric patients in India, there is a paucity of literature on the use of ENDF in Indian infants. Herein, we report the successful use of ENDF for the nutritional management of two infants hospitalized for growth faltering because of severe upper airway obstruction. The aim of nutritional management was to achieve satisfactory weight gain, which can lead to spontaneous resolution of upper airway obstruction. ENDF was initially administered to provide 50–100 kcal/kg/day, and the dose was gradually increased to 160–185 kcal/kg/day. Both infants tolerated the formula well and showed satisfactory weight gain. These cases clearly demonstrate that early administration of ENDF is an effective means of increasing nutrient and energy intake of critically ill infants, thereby facilitating catchup growth, without any notable adverse effects.

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          Most cited references38

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          Defining pediatric malnutrition: a paradigm shift toward etiology-related definitions.

          Lack of a uniform definition is responsible for underrecognition of the prevalence of malnutrition and its impact on outcomes in children. A pediatric malnutrition definitions workgroup reviewed existing pediatric age group English-language literature from 1955 to 2011, for relevant references related to 5 domains of the definition of malnutrition that were a priori identified: anthropometric parameters, growth, chronicity of malnutrition, etiology and pathogenesis, and developmental/ functional outcomes. Based on available evidence and an iterative process to arrive at multidisciplinary consensus in the group, these domains were included in the overall construct of a new definition. Pediatric malnutrition (undernutrition) is defined as an imbalance between nutrient requirements and intake that results in cumulative deficits of energy, protein, or micronutrients that may negatively affect growth, development, and other relevant outcomes. A summary of the literature is presented and a new classification scheme is proposed that incorporates chronicity, etiology, mechanisms of nutrient imbalance, severity of malnutrition, and its impact on outcomes. Based on its etiology, malnutrition is either illness related (secondary to 1 or more diseases/injury) or non-illness related, (caused by environmental/behavioral factors), or both. Future research must focus on the relationship between inflammation and illness-related malnutrition. We anticipate that the definition of malnutrition will continue to evolve with improved understanding of the processes that lead to and complicate the treatment of this condition. A uniform definition should permit future research to focus on the impact of pediatric malnutrition on functional outcomes and help solidify the scientific basis for evidence-based nutrition practices.
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            Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition

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              Regulation of muscle protein by amino acids.

              R Wolfe (2002)
              Amino acid availability is a potent regulator of muscle protein synthesis (MPS). We have performed a series of studies using stable isotope methodology and the arteriovenous balance approach to quantify many aspects of the response of MPS, breakdown, and the balance between synthesis and breakdown to changes in the availability of amino acids. A constant intake of amino acids stimulates MPS in a dose-dependent manner until concentrations are approximately doubled, after which further increases in concentration are ineffective. MPS rises more rapidly after bolus ingestion to a peak rate of MPS higher than during constant intake, but the response is transient. A reduction in amino acid availability below basal levels inhibits MPS. Ingestion of nonessential amino acids is not needed to stimulate MPS. When carbohydrate alone is ingested there is minimal effect on MPS, but there is an interactive effect with amino acid ingestion, meaning the response to amino acids plus glucose is more than the sum of their individual effects. Finally, acute anabolic responses in net MPS correspond quantitatively to differences in 24-h net muscle balances.
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                Author and article information

                Contributors
                Journal
                Front Nutr
                Front Nutr
                Front. Nutr.
                Frontiers in Nutrition
                Frontiers Media S.A.
                2296-861X
                26 February 2021
                2021
                : 8
                : 588177
                Affiliations
                [1] 1Department of Pediatric Critical Care, Ankura Children's Hospital , Hyderabad, India
                [2] 2Department of Pediatric Critical Care, NICE Hospital for Women, Newborns and Children , Hyderabad, India
                [3] 3Healthcare Nutrition Science, Nutricia International Pvt. Ltd. , Mumbai, India
                Author notes

                Edited by: Lidia Santarpia, University of Naples Federico II, Italy

                Reviewed by: Avula Laxmaiah, Indian Council of Medical Research, India; Emmanouella Magriplis, Agricultural University of Athens, Greece

                *Correspondence: Shikha Bhatia shikha.bhatia@ 123456danone.com

                This article was submitted to Clinical Nutrition, a section of the journal Frontiers in Nutrition

                Article
                10.3389/fnut.2021.588177
                7952321
                f3f0c579-daa2-43a7-88bc-61a84a14c5a8
                Copyright © 2021 Kareem, Panuganti and Bhatia.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 28 July 2020
                : 22 January 2021
                Page count
                Figures: 2, Tables: 1, Equations: 0, References: 39, Pages: 8, Words: 5452
                Categories
                Nutrition
                Case Report

                endf,india,infant,growth faltering,picu,nutritional management,catchup growth

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