Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis.

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Abstract

Organic anion-transporting polypeptides OATP1B1 and OATP1B3 are sinusoidal membrane transporters mediating liver uptake of a wide range of substrates including conjugated and unconjugated bilirubin, xenobiotics and drugs. Absence of OATP1Bs in the liver causes Rotor syndrome. Our aim was to correlate OATP1B expression with hyperbilirubinemia in common liver diseases.

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Journal

Journal ID (iso-abbrev): Int J Clin Exp Pathol

Title: International journal of clinical and experimental pathology

Publisher:

ISSN (Electronic): 1936-2625

ISSN (Print): 1936-2625

Publication date (Electronic): 2015

Volume: 8

Issue: 5

Affiliations

[1 ] Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine 14021 Prague 4, Czech Republic ; Third Faculty of Medicine, Charles University 10000 Prague 10, Czech Republic.

[2 ] Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine 14021 Prague 4, Czech Republic.

[3 ] The Netherlands Cancer Institute Amsterdam, The Netherlands ; TNO Zeist, The Netherlands.

[4 ] Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine 14021 Prague 4, Czech Republic.

[5 ] Medical Statistics Unit, Institute for Clinical and Experimental Medicine 14021 Prague 4, Czech Republic.

[6 ] 2nd Department of Pediatrics of The 2nd Medical School, Charles University Prague, Czech Republic.

[7 ] The Netherlands Cancer Institute Amsterdam, The Netherlands.

[8 ] Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine 14021 Prague 4, Czech Republic.

Article

PMC ID: 4503098

PubMed ID: 26191226

SO-VID: f2d7c585-c433-4691-b42a-db757028548b

History

Keywords: organic anion transporter,liver disease,immunohistochemistry,cholestasis,Bilirubin

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Keywords: organic anion transporter, liver disease, immunohistochemistry, cholestasis, Bilirubin

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