Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7.

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Abstract

Sorafenib (Sora) represents one of the few effective drugs for the treatment of advanced hepatocellular carcinoma (HCC), while resistance and cardiotoxicity limit its therapeutic efficacy. This study investigated the effect of transient receptor potential melastatin 7 (TRPM7) inhibitor, carvacrol (CARV), on overcoming Sora resistance and cardiotoxicity in thioacetamide (TAA) induced HCC in rats.

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Journal

Journal ID (iso-abbrev): Life Sci

Title: Life sciences

Publisher: Elsevier BV

ISSN (Electronic): 1879-0631

ISSN (Print): 0024-3205

Publication date (Electronic): Jul 01 2023

Volume: 324

Affiliations

[1 ] Biochemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt; Biochemistry Department, Faculty of Pharmacy, Horus University-Egypt, Damietta 34511, Egypt. Electronic address: eman.hamdi@std.mans.edu.eg.

[2 ] Biochemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

Article

Publisher Item ID: S0024-3205(23)00369-7

DOI: 10.1016/j.lfs.2023.121735

PubMed ID: 37142088

SO-VID: f2d661aa-e68a-4562-8014-8a7238ddbc0d

History

Keywords: Drug resistance,Tumor microenvironment,Oxidative stress,Hypoxia-inducible factor 1 alpha,Epithelial mesenchymal transition,Cancer stemness

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Keywords: Drug resistance, Tumor microenvironment, Oxidative stress, Hypoxia-inducible factor 1 alpha, Epithelial mesenchymal transition, Cancer stemness

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