Causal effect of sex hormone-binding globulin and testosterone on coronary heart disease: A multivariable and network Mendelian randomization analysis.

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Abstract

Although observational studies have shown an association between sex hormone-binding globulin (SHBG), testosterone (T) and cardiovascular diseases (CVD), controversy remains. In this study, we aim to explore the causal effects of SHBG and T on Coronary heart disease (CHD).

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Journal

Journal ID (iso-abbrev): Int J Cardiol

Title: International journal of cardiology

Publisher: Elsevier BV

ISSN (Electronic): 1874-1754

ISSN (Print): 0167-5273

Publication date (Electronic): September 15 2021

Volume: 339

Affiliations

[1 ] Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China.

[2 ] Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China; Institute for Medical Dataology, Shandong University, Jinan 250002, PR China.

[3 ] Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China; Institute for Medical Dataology, Shandong University, Jinan 250002, PR China. Electronic address: liu-yx@sdu.edu.cn.

[4 ] Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China; Institute for Medical Dataology, Shandong University, Jinan 250002, PR China. Electronic address: xuefzh@sdu.edu.cn.

Article

Publisher Item ID: S0167-5273(21)01035-4

DOI: 10.1016/j.ijcard.2021.06.037

PubMed ID: 34181993

SO-VID: f24a4189-989d-4735-b0d1-8b86595f0595

History

Keywords: SHBG,Mendelian randomization,Coronary heart disease,Causal effect,Testosterone

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Keywords: SHBG, Mendelian randomization, Coronary heart disease, Causal effect, Testosterone

Causal effect of sex hormone-binding globulin and testosterone on coronary heart disease: A multivariable and network Mendelian randomization analysis.

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Sex hormones and lung development

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