25
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Analysis of contact pressure in a 3D model of dual-mobility hip joint prosthesis under a gait cycle

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Hip joint prostheses are used to replace hip joint function in the human body. The latest dual-mobility hip joint prosthesis has an additional component of an outer liner that acts as a cover for the liner component. Research on the contact pressure generated on the latest model of a dual-mobility hip joint prosthesis under a gait cycle has never been done before. The model is made of ultrahigh molecular weight polyethylene (UHMWPE) on the inner liner and 316L stainless steel (SS 316L) on the outer liner and acetabular cup. Simulation modeling using the finite element method is considered static loading with an implicit solver for studying the geometric parameter design of dual-mobility hip joint prostheses. In this study, simulation modeling was carried out by applying varying inclination angles of 30°, 40°, 45°, 50°, 60°, and 70° to the acetabular cup component. Three-dimensional loads were placed on femoral head reference points with variations of femoral head diameter used at 22 mm, 28 mm, and 32 mm. The results in the inner surface of the inner liner, the outer surface of the outer liner, and the inner surface of the acetabular cup showed that the variations in inclination angle do not have a major effect on the maximum contact pressure value on the liner component, where the acetabular cup with an inclination angle of 45° can reduce contact pressure more than the other studied inclination angle variations. In addition, it was found that the 22 mm diameter of the femoral head increases the contact pressure. The use of a larger diameter femoral head with an acetabular cup configuration at a 45° inclination can minimize the risk of implant failure due to wear.

          Related collections

          Most cited references52

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

          Krabbe disease (KD) is a neurodegenerative disorder caused by the lack of β- galactosylceramidase enzymatic activity and by widespread accumulation of the cytotoxic galactosyl-sphingosine in neuronal, myelinating and endothelial cells. Despite the wide use of Twitcher mice as experimental model for KD, the ultrastructure of this model is partial and mainly addressing peripheral nerves. More details are requested to elucidate the basis of the motor defects, which are the first to appear during KD onset. Here we use transmission electron microscopy (TEM) to focus on the alterations produced by KD in the lower motor system at postnatal day 15 (P15), a nearly asymptomatic stage, and in the juvenile P30 mouse. We find mild effects on motorneuron soma, severe ones on sciatic nerves and very severe effects on nerve terminals and neuromuscular junctions at P30, with peripheral damage being already detectable at P15. Finally, we find that the gastrocnemius muscle undergoes atrophy and structural changes that are independent of denervation at P15. Our data further characterize the ultrastructural analysis of the KD mouse model, and support recent theories of a dying-back mechanism for neuronal degeneration, which is independent of demyelination.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            Molecular analysis of chromium and cobalt-related toxicity

            Occupational and environmental exposure to Co and Cr has been previously linked to a wide array of inflammatory and degenerative conditions and cancer. Recently, significant health concerns have been raised by the high levels of Cr and Co ions and corrosion products released by biomedical implants. Herein, we set to analyze the biological responses associated with Co and Cr toxicity. Histological, ultrastructural, and elemental analysis, performed on Cr and Co exposed patients reveal the presence of corrosion products, metallic wear debris and metal ions at varying concentrations. Metallic ions and corrosion products were also generated in vitro following macrophage phagocytosis of metal alloys. Ex vivo redox proteomic mapped several oxidatively damaged proteins by Cr(III) and Co(II)-induced Fenton reaction. Importantly, a positive correlation between the tissue amounts of Cr(III) and Co(II) ions and tissue oxidative damage was observed. Immobilized- Cr(III) and Co(II) affinity chromatography indicated that metal ions can also directly bind to several metallo and non-metalloproteins and, as demonstrated for aldolase and catalase, induce loss of their biological function. Altogether, our analysis reveals several biological mechanisms leading to tissue damage, necrosis, and inflammation in patients with Cr and Co-associated adverse local tissue reactions.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Scaling of titanium implants entrains inflammation-induced osteolysis

              With millions of new dental and orthopedic implants inserted annually, periprosthetic osteolysis becomes a major concern. In dentistry, peri-implantitis management includes cleaning using ultrasonic scaling. We examined whether ultrasonic scaling releases titanium particles and induces inflammation and osteolysis. Titanium discs with machined, sandblasted/acid-etched and sandblasted surfaces were subjected to ultrasonic scaling and we physically and chemically characterized the released particles. These particles induced a severe inflammatory response in macrophages and stimulated osteoclastogenesis. The number of released particles and their chemical composition and nanotopography had a significant effect on the inflammatory response. Sandblasted surfaces released the highest number of particles with the greatest nanoroughness properties. Particles from sandblasted/acid-etched discs induced a milder inflammatory response than those from sandblasted discs but a stronger inflammatory response than those from machined discs. Titanium particles were then embedded in fibrin membranes placed on mouse calvariae for 5 weeks. Using micro-CT, we observed that particles from sandblasted discs induced more osteolysis than those from sandblasted/acid-etched discs. In summary, ultrasonic scaling of titanium implants releases particles in a surface type-dependent manner and may aggravate peri-implantitis. Future studies should assess whether surface roughening affects the extent of released wear particles and aseptic loosening of orthopedic implants.
                Bookmark

                Author and article information

                Contributors
                mohammad.tauviqirrahman@ft.undip.ac.id
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                2 March 2023
                2 March 2023
                2023
                : 13
                : 3564
                Affiliations
                [1 ]GRID grid.412032.6, ISNI 0000 0001 0744 0787, Department of Mechanical Engineering, Faculty of Engineering, , Diponegoro University, ; Semarang, 50275 Central Java Indonesia
                [2 ]GRID grid.443096.c, ISNI 0000 0000 9620 8826, Department of Mechanical Engineering, Faculty of Engineering, , Pasundan University, ; Bandung, 40153 West Java Indonesia
                [3 ]GRID grid.443096.c, ISNI 0000 0000 9620 8826, Biomechanics and Biomedics Engineering Research Centre, , Pasundan University, ; Bandung, 40153 West Java Indonesia
                [4 ]GRID grid.412032.6, ISNI 0000 0001 0744 0787, Undip Biomechanics Engineering and Research Centre (UBM-ERC), , Diponegoro University, ; Semarang, 50275 Central Java Indonesia
                [5 ]Department of Mechanical Engineering, Semarang State Polytechnic, Semarang, 50275 Central Java Indonesia
                [6 ]GRID grid.412032.6, ISNI 0000 0001 0744 0787, Department of Anatomy, Faculty of Medicine, , Diponegoro University, ; Semarang, 50275 Central Java Indonesia
                [7 ]GRID grid.412032.6, ISNI 0000 0001 0744 0787, Center for Biomedical Research (CEBIOR), Faculty of Medicine, , Diponegoro University, ; Semarang, 50275 Central Java Indonesia
                [8 ]GRID grid.6214.1, ISNI 0000 0004 0399 8953, Department of Mechanics of Solids, Surfaces and Systems (MS3), Faculty of Engineering Technology, , University of Twente, ; Postbox 217, 7500 AE Enschede, The Netherlands
                [9 ]GRID grid.6214.1, ISNI 0000 0004 0399 8953, Laboratory for Surface Technology and Tribology, Faculty of Engineering Technology, , University of Twente, ; Postbox 217, 7500 AE Enschede, The Netherlands
                Article
                30725
                10.1038/s41598-023-30725-6
                9981612
                36864170
                f234e22f-f63f-4f59-b23e-333fd676484b
                © The Author(s) 2023

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 29 April 2022
                : 28 February 2023
                Categories
                Article
                Custom metadata
                © The Author(s) 2023

                Uncategorized
                biomaterials,engineering,materials science,mathematics and computing
                Uncategorized
                biomaterials, engineering, materials science, mathematics and computing

                Comments

                Comment on this article

                scite_
                0
                0
                0
                0
                Smart Citations
                0
                0
                0
                0
                Citing PublicationsSupportingMentioningContrasting
                View Citations

                See how this article has been cited at scite.ai

                scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

                Similar content272

                Cited by19

                Most referenced authors1,359