Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis

Drexler, Stefan K; Kong, Philip L; Wales, Jeremy; Foxwell, Brian M. J.

doi:10.1186/ar2481

ScienceOpen: research and publishing network

For Publishers

For Researchers

Blog
About

Search
Advanced search

views

recommends

Record: found
Abstract: found
Article: not found

Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis

review-article

Author(s): Stefan K Drexler ¹ , Philip L Kong ¹ , Jeremy Wales ¹ , Brian M Foxwell ¹ ^,

Publication date (Electronic): 10 October 2008

Journal: Arthritis Research & Therapy

Publisher: BioMed Central

Read this article at

ScienceOpenPublisher PMC

Bookmark

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the population and leading to the destruction of the joints. Evidence exists for the involvement of the innate as well as the adaptive immune systems in the pathology of the disease. The success of anti-tumour necrosis factor-α indicates the importance of pro-inflammatory mediators produced by innate immune cells in rheumatoid arthritis progression. Therefore, considerable efforts have been made in elucidating the signalling pathways leading to the expression of those mediators. This review will concentrate on the role of signalling pathways in innate immune cells in the context of rheumatoid arthritis.

Related collections

Most cited references 126

Record: found
Abstract: found
Article: not found

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.

Kenya Honda, Tadatsugu Taniguchi (2006)

The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown to have functionally diverse roles in the regulation of the immune system. Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll-like receptors and other pattern-recognition receptors.

0 comments Cited 497 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.

Osamu Adachi, Taro Kawai, Kiyoshi Takeda … (1998)

MyD88, originally isolated as a myeloid differentiation primary response gene, is shown to act as an adaptor in interleukin-1 (IL-1) signaling by interacting with both the IL-1 receptor complex and IL-1 receptor-associated kinase (IRAK). Mice generated by gene targeting to lack MyD88 have defects in T cell proliferation as well as induction of acute phase proteins and cytokines in response to IL-1. Increases in interferon-gamma production and natural killer cell activity in response to IL-18 are abrogated. In vivo Th1 response is also impaired. Furthermore, IL-18-induced activation of NF-kappaB and c-Jun N-terminal kinase (JNK) is blocked in MyD88-/- Th1-developing cells. Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor.

0 comments Cited 493 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

IL-17 family cytokines and the expanding diversity of effector T cell lineages.

Casey T. Weaver, Robin Hatton, Paul R Mangan … (2007)

Since its conception two decades ago, the Th1-Th2 paradigm has provided a framework for understanding T cell biology and the interplay of innate and adaptive immunity. Naive T cells differentiate into effector T cells with enhanced functional potential for orchestrating pathogen clearance largely under the guidance of cytokines produced by cells of the innate immune system that have been activated by recognition of those pathogens. This secondary education of post-thymic T cells provides a mechanism for appropriately matching adaptive immunity to frontline cues of the innate immune system. Owing in part to the rapid identification of novel cytokines of the IL-17 and IL-12 families using database searches, the factors that specify differentiation of a new effector T cell lineage-Th17-have now been identified, providing a new arm of adaptive immunity and presenting a unifying model that can explain many heretofore confusing aspects of immune regulation, immune pathogenesis, and host defense.

0 comments Cited 384 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): Arthritis Res Ther

Title: Arthritis Research & Therapy

Publisher: BioMed Central

ISSN (Print): 1478-6354

ISSN (Electronic): 1478-6362

Publication date (Print): 2008

Publication date (Electronic): 10 October 2008

Volume: 10

Issue: 5

Page: 216

Affiliations

[1 ]Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, 65 Aspenlea Road, Hammersmith, London, W6 8LH, UK

Article

Publisher ID: ar2481

DOI: 10.1186/ar2481

PMC ID: 2592774

PubMed ID: 18947379

SO-VID: f1eeee0a-84a6-4f52-bc93-18ae50a9b8c5

History

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.