Rapid assessment of regional SARS-CoV-2 community transmission through a convenience sample of healthcare workers, the Netherlands, March 2020

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Abstract

To rapidly assess possible community transmission in Noord-Brabant, the Netherlands, healthcare workers (HCW) with mild respiratory complaints and without epidemiological link (contact with confirmed case or visited areas with active circulation) were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within 2 days, 1,097 HCW in nine hospitals were tested; 45 (4.1%) were positive. Of six hospitals with positive HCW, two accounted for 38 positive HCW. The results informed local and national risk management.

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Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

Victor M Corman, Olfert Landt, Marco Kaiser … (2020)

Background The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak is more widespread than initially thought, and international spread through travellers does already occur. Aim We aimed to develop and deploy robust diagnostic methodology for use in public health laboratory settings without having virus material available. Methods Here we present a validated diagnostic workflow for 2019-nCoV, its design relying on close genetic relatedness of 2019-nCoV with SARS coronavirus, making use of synthetic nucleic acid technology. Results The workflow reliably detects 2019-nCoV, and further discriminates 2019-nCoV from SARS-CoV. Through coordination between academic and public laboratories, we confirmed assay exclusivity based on 297 original clinical specimens containing a full spectrum of human respiratory viruses. Control material is made available through European Virus Archive – Global (EVAg), a European Union infrastructure project. Conclusion The present study demonstrates the enormous response capacity achieved through coordination of academic and public laboratories in national and European research networks.

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Author and article information

Journal

Journal ID (nlm-ta): Euro Surveill

Journal ID (iso-abbrev): Euro Surveill

Journal ID (publisher-id): ES

Title: Eurosurveillance

Publisher: European Centre for Disease Prevention and Control (ECDC)

ISSN (Print): 1025-496X

ISSN (Electronic): 1560-7917

Publication date (Print): 26 March 2020

Volume: 25

Issue: 12

Electronic Location Identifier: 2000334

Affiliations

[1 ]Centre for Infectious Disease Control-National Institute for Public Health and the Environment, Bilthoven, the Netherlands

[2 ]These authors contributed equally to this work

[3 ]Elisabeth-Tweesteden hospital, Tilburg and Waalwijk, the Netherlands

[4 ]Radboudumc, Nijmegen, the Netherlands

[5 ]Bravis hospital, Roosendaal and Bergen-op-Zoom, the Netherlands.

[6 ]Nivel, Netherlands institute for health services research, Utrecht, the Netherlands

[7 ]Erasmus MC, Rotterdam, the Netherlands

[8 ]Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands

[9 ]Catharina hospital, Eindhoven, the Netherlands

[10 ]VieCuri hospital, Venlo, the Netherlands

[11 ]Amphia hospital, Breda, the Netherlands

[12 ]Elkerliek hospital, Helmond, the Netherlands

[13 ]Bernhoven hospital, Uden, the Netherlands

Author notes

Correspondence: Chantal Reusken ( chantal.reusken@ 123456rivm.nl )

Article

Publisher ID: 2000334 Publisher ID: 2000334

DOI: 10.2807/1560-7917.ES.2020.25.12.2000334

PMC ID: 7118342

PubMed ID: 32234115

SO-VID: f12daf82-6afb-44b0-a9ac-7e0bcf1012f0

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.

History

Date received : 16 March 2020

Date accepted : 25 March 2020

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