There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

A general rhodium-catalyzed oxidative coupling reaction between internal alkynes and aryl aldimines is described. This process affords 3,4-disubstituted isoquinolines in good yield and high regioselectivity. Preliminary mechanistic studies suggest that the C-N bond formation arises from the reductive elimination of a rhodium(III) species.

Related collections

Author and article information

Journal

PubMed ID:: 19705909

DOI:: 10.1021/ja904380q

Data availability:

Comments

Comment on this article

scite_

Isoquinoline synthesis via rhodium-catalyzed oxidative cross-coupling/cyclization of aryl aldimines and alkynes.

Read this article at

Synthesis of 2-trifluoromethylated piperidines and azepanes

Journal

Comment on this article