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      Contact inhibition of migrating lens epithelial cells at the capsular bend created by a sharp-edged intraocular lens after cataract surgery

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      Journal of Cataract & Refractive Surgery
      Elsevier BV

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          Abstract

          To investigate whether the lens epithelial cells (LECs) at the capsular bend created by a sharp-edged intraocular lens (IOL) are in the G(0) phase of the cell cycle. Nishi Eye Hospital, Osaka, Japan. A CeeOn Edge silicone IOL (AMO) with sharp edges was implanted in 1 eye and a PhacoFlex II silicone IOL (AMO) with rounded edges in the contralateral eye after standard cataract surgery in 6 rabbits. Immunohistochemical staining for the Ki-67 antibody was performed 1 day, 3, 4, and 7 weeks after surgery. In eyes with the sharp-edged IOL, LECs with thin, elongated nuclei accumulated at, but did not extend beyond, the capsular bend and stained negative for the Ki-67 antibody, indicating that they were in the G(0) phase of the cell cycle. In contrast, in the eye with the round-edged IOL, continuous migration of a predominantly monolayer of LECs over the IOL and onto the posterior capsule occurred. These cells were Ki-67 positive, indicating that they were proliferating. Lens epithelial cells at the capsular bend of sharp-edged IOLs were in the G(0) phase of the cell cycle, indicating that they were contact inhibited. These findings support the theory the sharp posterior optic edge of the IOL inhibits LEC migration, reducing formation of posterior capsule opacification. Whether these LECs can reactivate when the capsular bend is eliminated by later formation of a Soemmerring's ring requires further studies.

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          Author and article information

          Journal
          Journal of Cataract & Refractive Surgery
          Journal of Cataract & Refractive Surgery
          Elsevier BV
          08863350
          June 2007
          June 2007
          : 33
          : 6
          : 1065-1070
          Article
          10.1016/j.jcrs.2007.02.022
          17531703
          efa8b323-5b53-47cf-91a4-331383e04bd7
          © 2007

          https://www.elsevier.com/tdm/userlicense/1.0/

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