ABO-immune complex formation and impact on platelet function, red cell structural integrity and haemostasis: an in vitro model of ABO non-identical transfusion.

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Abstract

Transfusion of ABO non-identical platelets has been associated with fatal haemolytic reactions, increased red cell transfusion needs and other adverse effects, but the practice of ABO matching in platelet transfusion is controversial. Immune complexes can be formed from the anti-A and/or anti-B antibodies and ABO soluble antigen(s) present in donor and recipient plasma after ABO non-identical transfusions. We hypothesized that these immune complexes affect recipient red cell structural integrity, platelet function and haemostasis.

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Author and article information

Journal

Journal ID (iso-abbrev): Vox Sang.

Title: Vox sanguinis

Publisher: Wiley

ISSN (Electronic): 1423-0410

ISSN (Print): 0042-9007

Publication date (Electronic): Apr 2016

Volume: 110

Issue: 3

Affiliations

[1 ] James P. Wilmot Cancer Center, University of Rochester Medicine, Rochester, NY, USA.

[2 ] Department of Medicine, University of Rochester Medicine, Rochester, NY, USA.

[3 ] Department of Pathology and Laboratory Medicine, University of Rochester Medicine, Rochester, NY, USA.

Article

DOI: 10.1111/vox.12354

PubMed ID: 26528766

SO-VID: ef6e9760-e0b9-42d2-882b-2d6ed26ccfd2

History

Keywords: transfusion complications,thromboelastography,haemolysis,platelet aggregation,immune complex,platelet transfusion

Data availability:

Keywords: transfusion complications, thromboelastography, haemolysis, platelet aggregation, immune complex, platelet transfusion

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