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Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial
Estelle C Nijssen ,
Roger J Rennenberg ,
Patty J Nelemans ,
Brigitte A Essers ,
Marga M Janssen ,
Marja A Vermeeren ,
Vincent van Ommen ,
Joachim E Wildberger
April 2017
April 2017
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Abstract
Intravenous saline is recommended in clinical practice guidelines as the cornerstone
for preventing contrast-induced nephropathy in patients with compromised renal function.
However, clinical-effectiveness and cost-effectiveness of this prophylactic hydration
treatment in protecting renal function has not been adequately studied in the population
targeted by the guidelines, against a group receiving no prophylaxis. This was the
aim of the AMACING trial.
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