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      Renoprotective effect of erythropoietin in zebrafish after administration of gentamicin: an immunohistochemical study for β-catenin and c-kit expression.

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          Abstract

          Gentamicin is an aminoglycoside antibiotic widely used in the treatment of infections caused by Gram-negative bacteria. The main limitation to its therapeutic effectiveness is the potential nephrotoxicity. Erythropoietin has a tissue protective effect widely demonstrated in the kidney. The aim of the present study was to evaluate the renoprotective effects of erythropoietin in a model of zebrafish (Danio rerio) after administration of gentamicin.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): J. Nephrol.
          Title: Journal of nephrology
          Publisher: Springer Nature
          ISSN (Electronic): 1724-6059
          ISSN (Print): 1121-8428
          Publication date (Electronic): Jun 2017
          Volume: 30
          Issue: 3
          Affiliations
          [1 ] Chair of Nephrology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria n. 1, 98124, Messina, Italy. valecern82@virgilio.it.
          [2 ] Department of Veterinary Science, University of Messina, 98100, Messina, Italy.
          [3 ] IAMC (Institute for Coastal Marine Environment), CNR, U.O.S. Messina, Spianata S. Raineri, 86, 98122, Messina, Italy.
          [4 ] Chair of Nephrology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria n. 1, 98124, Messina, Italy.
          Article
          Publisher Item ID: 10.1007/s40620-016-0353-y
          DOI: 10.1007/s40620-016-0353-y
          PubMed ID: 27679401
          SO-VID: eee14a00-b7bd-4be6-baea-4ed8c54395b0
          History

          Keywords: Erythropoietin,Gentamicin,Tubule regeneration,Zebrafish,c-Kit,β-Catenin
          Data availability:
          Keywords: Erythropoietin, Gentamicin, Tubule regeneration, Zebrafish, c-Kit, β-Catenin

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