Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

The advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials.

Main body

Sericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells.

Conclusion

In this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications.

Related collections

Most cited references 109

Record: found
Abstract: found
Article: found

Is Open Access

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

Parisa Foroozandeh, Azlan Aziz (2018)

Nanoparticle science is rapidly changing the landscape of various scientific fields and defining new technological platforms. This is perhaps even more evident in the field of nanomedicine whereby nanoparticles have been used as a tool for the treatment and diagnosis of many diseases. However, despite the tremendous benefit conferred, common pitfalls of this technology is its potential short and long-term effects on the human body. To understand these issues, many scientific studies have been carried out. This review attempts to shed light on some of these studies and its outcomes. The topics that were examined in this review include the different possible uptake pathways of nanoparticles and intracellular trafficking routes. Additionally, the effect of physicochemical properties of nanoparticle such as size, shape, charge and surface chemistry in determining the mechanism of uptake and biological function of nanoparticles are also addressed.

0 comments Cited 353 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

The Biomedical Use of Silk: Past, Present, Future

Chris Holland, Keiji Numata, Jelena Rnjak-Kovacina … (2019)

0 comments Cited 183 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages

Dagmar Kuhn, Dimitri Vanhecke, Benjamin Michen … (2014)

Summary Precise knowledge regarding cellular uptake of nanoparticles is of great importance for future biomedical applications. Four different endocytotic uptake mechanisms, that is, phagocytosis, macropinocytosis, clathrin- and caveolin-mediated endocytosis, were investigated using a mouse macrophage (J774A.1) and a human alveolar epithelial type II cell line (A549). In order to deduce the involved pathway in nanoparticle uptake, selected inhibitors specific for one of the endocytotic pathways were optimized regarding concentration and incubation time in combination with fluorescently tagged marker proteins. Qualitative immunolocalization showed that J774A.1 cells highly expressed the lipid raft-related protein flotillin-1 and clathrin heavy chain, however, no caveolin-1. A549 cells expressed clathrin heavy chain and caveolin-1, but no flotillin-1 uptake-related proteins. Our data revealed an impeded uptake of 40 nm polystyrene nanoparticles by J774A.1 macrophages when actin polymerization and clathrin-coated pit formation was blocked. From this result, it is suggested that macropinocytosis and phagocytosis, as well as clathrin-mediated endocytosis, play a crucial role. The uptake of 40 nm nanoparticles in alveolar epithelial A549 cells was inhibited after depletion of cholesterol in the plasma membrane (preventing caveolin-mediated endocytosis) and inhibition of clathrin-coated vesicles (preventing clathrin-mediated endocytosis). Our data showed that a combination of several distinguishable endocytotic uptake mechanisms are involved in the uptake of 40 nm polystyrene nanoparticles in both the macrophage and epithelial cell line.

0 comments Cited 154 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Jayanta Kumar Patra:

ORCID: http://orcid.org/0000-0003-4118-4355

jkpatra.cet@gmail.com

Journal

Journal ID (nlm-ta): J Nanobiotechnology

Journal ID (iso-abbrev): J Nanobiotechnology

Title: Journal of Nanobiotechnology

Publisher: BioMed Central (London )

ISSN (Electronic): 1477-3155

Publication date (Electronic): 22 January 2021

Publication date PMC-release: 22 January 2021

Publication date Collection: 2021

Volume: 19

Electronic Location Identifier: 30

Affiliations

[1 ]GRID grid.255168.d, ISNI 0000 0001 0671 5021, Research Institute of Biotechnology & Medical Converged Science, , Dongguk University-Seoul, ; Goyangsi, 10326 Republic of Korea

[2 ]GRID grid.255168.d, ISNI 0000 0001 0671 5021, Department of Food Science & Biotechnology, , Dongguk University-Seoul, ; Goyangsi, 10326 Republic of Korea

[3 ]GRID grid.412368.a, ISNI 0000 0004 0643 8839, Human and Natural Sciences Center, , Federal University of ABC. Av. Dos Estados, ; 5001. Bl. A, T3, Lab. 503-3. Bangú, Santo André, SP Brazil

[4 ]GRID grid.410543.7, ISNI 0000 0001 2188 478X, Institute of Science and Technology of Sorocaba, , São Paulo State University (UNESP), ; Av. Três de março, 511, Alto da Boa Vista, Sorocaba, São Paulo 18087-180 Brazil

[5 ]GRID grid.9486.3, ISNI 0000 0001 2159 0001, Departamento de Ingenieria Molecular de Materiales, Centro de Fisica Aplicada y Tecnologia Avanzada, , Universidad Nacional Autonoma de Mexico, ; Blvd. Juriquilla 3001, 76230 Queretaro, Qro Mexico

[6 ]Sustainability of Natural Resources and Energy Programs, Cinvestav-Saltillo, 25900 Coahuila, C.P. Mexico

[7 ]GRID grid.410543.7, ISNI 0000 0001 2188 478X, Department of Physics and Chemistry, , São Paulo State University (UNESP), ; Avenida Brasil, 56, Centro, Ilha Solteira, SP 15385-000 Brazil

Author information

Gitishree Das https://orcid.org/0000-0002-5676-0768

Estefânia V. Ramos Campos https://orcid.org/0000-0002-9420-7461

Leonardo Fernandes Fraceto https://orcid.org/0000-0002-2827-2038

Renato Grillo https://orcid.org/0000-0002-0284-5782

Jayanta Kumar Patra http://orcid.org/0000-0003-4118-4355

Article

Publisher ID: 774

DOI: 10.1186/s12951-021-00774-y

PMC ID: 7821414

SO-VID: eedad15f-64e4-4a79-b6aa-f4aa432102d7

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 16 October 2020

Date accepted : 9 January 2021

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100003725, National Research Foundation of Korea;

Award ID: 2020R1G1A1004667

Award Recipient : Jayanta Kumar Patra

Custom metadata

ScienceOpen disciplines: Biotechnology

Keywords: sericin,biomaterials,drug delivery,nanoformulation,biomedical,silk protein

Data availability:

ScienceOpen disciplines: Biotechnology

Keywords: sericin, biomaterials, drug delivery, nanoformulation, biomedical, silk protein

Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications

Read this article at

Abstract

Background

Main body

Conclusion

Related collections

Electrospinning for biomedical applications

Most cited references 109

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

The Biomedical Use of Silk: Past, Present, Future

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages

Author and article information

Contributors

Journal

Affiliations

Author information

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 108

Cited by 25

Most referenced authors 899