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      Dealing With Brain MRI Findings in Pediatric Patients With Endocrinological Conditions: Less Is More?

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          Abstract

          Neuroimaging is a key tool in the diagnostic process of various clinical conditions, especially in pediatric endocrinology. Thanks to continuous and remarkable technological developments, magnetic resonance imaging can precisely characterize numerous structural brain anomalies, including the pituitary gland and hypothalamus. Sometimes the use of radiological exams might become excessive and even disproportionate to the patients’ medical needs, especially regarding the incidental findings, the so-called “incidentalomas”. This unclarity is due to the absence of well-defined pediatric guidelines for managing and following these radiological findings. We review and summarize some indications on how to, and even if to, monitor these anomalies over time to avoid unnecessary, expensive, and time-consuming investigations and to encourage a more appropriate follow-up of brain MRI anomalies in the pediatric population with endocrinological conditions.

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          Most cited references60

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          Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society.

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            Pituitary Incidentaloma: An Endocrine Society Clinical Practice Guideline

            Practice guidelines for the endocrine evaluation and treatment of pituitary incidentalomas are presented, including indications for surgery.
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              Causes, diagnosis, and treatment of central precocious puberty.

              Central precocious puberty results from the premature activation of the hypothalamic-pituitary-gonadal axis. It mimics physiological pubertal development, although at an inappropriate chronological age (before 8 years in girls and 9 years in boys). It can be attributable to cerebral congenital malformations or acquired insults, but the cause in most cases in girls remains unknown. MKRN3 gene defects have been identified in familial disease, with important basic and clinical results. Indeed, genetic analysis of this gene should be included in the routine clinical investigation of familial and idiopathic cases of central precocious puberty. Gonadotropin-releasing hormone agonists are the gold-standard treatment. The assessment and management of this disease remain challenging for paediatric endocrinologists. In this Series paper, we describe current challenges involving the precise diagnosis and adequate treatment of this disorder.
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                Author and article information

                Contributors
                Journal
                Front Endocrinol (Lausanne)
                Front Endocrinol (Lausanne)
                Front. Endocrinol.
                Frontiers in Endocrinology
                Frontiers Media S.A.
                1664-2392
                12 January 2022
                2021
                : 12
                : 780763
                Affiliations
                [1] 1 University of Trieste , Trieste, Italy
                [2] 2 Institute for Maternal and Child Health IRCCS “Burlo Garofolo” , Trieste, Italy
                Author notes

                Edited by: Sasha R. Howard, Queen Mary University of London, United Kingdom

                Reviewed by: Alan David Rogol, University of Virginia, United States; Nikolina Kyprianou, Birmingham Children’s Hospital, United Kingdom

                *Correspondence: Maura Marin, maura_marin@ 123456me.com

                This article was submitted to Pediatric Endocrinology, a section of the journal Frontiers in Endocrinology

                Article
                10.3389/fendo.2021.780763
                8791386
                35095759
                eebcbb0a-a24a-4c72-9cba-2d52a0c64539
                Copyright © 2022 Baldo, Marin, Murru, Barbi and Tornese

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 21 September 2021
                : 20 December 2021
                Page count
                Figures: 0, Tables: 1, Equations: 0, References: 60, Pages: 6, Words: 2369
                Categories
                Endocrinology
                Perspective

                Endocrinology & Diabetes
                incidentaloma,growth hormone deficiency,central precocious puberty,incidental radiological finding,follow-up

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