Costunolide enhances cisplatin-induced cytotoxicity in hypopharyngeal SCC FaDu cells by increasing the production of reactive oxygen species.

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Abstract

The sesquiterpene lactone costunolide (CTL) has attracted much attention due to its antitumor effect on a variety of malignant tumors. However, the effect of CTL on hypopharyngeal squamous cell carcinoma (HSCC) remains unclear. This study aimed to examine the effects of this sesquiterpene lactone on HSCC FaDu cells.

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Author and article information

Journal

Journal ID (iso-abbrev): Pathol Res Pract

Title: Pathology, research and practice

Publisher: Elsevier BV

ISSN (Electronic): 1618-0631

ISSN (Print): 0344-0338

Publication date (Electronic): Aug 2022

Volume: 236

Affiliations

[1 ] Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China; Department of General Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.

[2 ] Department of Oncology, Shaanxi Provincial People's Hospital, Xi'an 710068, China.

[3 ] Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China; Department of General Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China. Electronic address: chzheng@xjtu.edu.cn.

[4 ] Department of Radiology, Shaanxi Provincial People's Hospital, Xi'an 710068, China. Electronic address: kmq9876@126.com.

Article

Publisher Item ID: S0344-0338(22)00210-2

DOI: 10.1016/j.prp.2022.153966

PubMed ID: 35679753

SO-VID: ee1c19f9-645d-459d-aa8a-b1cfd21872e8

History

Keywords: AKT,Costunolide,Apoptosis,HSCC,NF-κB,ROS

Data availability:

Keywords: AKT, Costunolide, Apoptosis, HSCC, NF-κB, ROS

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