Influence of nature and macromolecular characteristics of carrier polymer on immobilization of bolaform ions

Abstract

The study of the interactions of polyelectrolytes with organic ions and especially with ions of physiologically active substances is of particular. There are wide ranges of polymers used for these purposes, the most convenient “substrate” is considered to be synthetic carriers that are easily regulated during production. The object of research was the antiprotozoal drug azidine, widely used in veterinary practice, which, when dissolved in water, forms a complex bolaform cation: 4.41-diamidinodiazoaminobenzene. To develop a prolonged dosage form for veterinary medicine, the binding of this substance with various synthetic polymers such as polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic, and polymethacrylic acids are important. In addition; their copolymers, was studied using physical and chemical methods. The influence of the nature of the carrier polymer, the molecular weight, and the conformation of macromolecules on the process of binding organic ions were also examined.The results obtained were confirmed by in vivo tests on cattle. A pattern is shown between the strength of the bond of the drug substance with the polymer carrier and the time of its preventive action.