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      Severe pneumonia due to Nocardia otitidiscaviarum identified by mass spectroscopy in a cotton farmer : A case report and literature review

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          Abstract

          Rationale:

          Nocardia species are aerobic saprophytic bacilli. Among Nocardia species, Nocardia otitidiscaviarum ( N otitidiscaviarum) is rarely reported in pulmonary infection.

          Patient concerns:

          We reported a case of N otitidiscaviarum pneumonia in a cotton farmer.

          Diagnoses:

          N otitidiscaviarum pneumonia was identified by mass spectroscopy.

          Interventions:

          Combined treatments (amikacin, imipenem and trimethoprim-sulfamethoxazole) were administered after identification of N otitidiscaviarum.

          Outcomes:

          The patient eventually died from severe respiratory insufficiency in the hospital.

          Lessons:

          Early precise diagnosis and prompt combined therapy are of vital importance in severe Nocardia pulmonary infection.

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          Most cited references28

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          Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy.

          The recent explosion of newly described species of Nocardia results from the impact in the last decade of newer molecular technology, including PCR restriction enzyme analysis and 16S rRNA sequencing. These molecular techniques have revolutionized the identification of the nocardiae by providing rapid and accurate identification of recognized nocardiae and, at the same time, revealing new species and a number of yet-to-be-described species. There are currently more than 30 species of nocardiae of human clinical significance, with the majority of isolates being N. nova complex, N. abscessus, N. transvalensis complex, N. farcinica, N. asteroides type VI (N. cyriacigeorgica), and N. brasiliensis. These species cause a wide variety of diseases and have variable drug susceptibilities. Accurate identification often requires referral to a reference laboratory with molecular capabilities, as many newer species are genetically distinct from established species yet have few or no distinguishing phenotypic characteristics. Correct identification is important in deciding the clinical relevance of a species and in the clinical management and treatment of patients with nocardial disease. This review characterizes the currently known pathogenic species of Nocardia, including clinical disease, drug susceptibility, and methods of identification.
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            Nocardiosis: review of clinical and laboratory experience.

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              Nocardial infections in the United States, 1972-1974.

              A survey of members of the Infectious Diseases Society of America indicated that nocardial infections are not rare. Probably between 500 and 1,000 cases are recognized in the United States each year, of which 85% are serious pulmonary or systemic infections. Although nocardial infections are usually opportunistic infections in the compromised host, at least 15% of the infections in this series occurred in patients without a definable predisposing condition. Nocardial infections occurred in a random geographic distribution within this country, with affected males outnumbering females by 3:1. Most patients were between the ages of 21 and 50 years; however, the age range was broad. The number and variety of infections caused by Nocardia species other than Nocardia species other than Nocardia asteroides have been underestimated. Between 8.6% and 18.8% of pulmonary-systemic infections in this series were caused by species of Nocardia other than N. asteroides.
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                Author and article information

                Journal
                Medicine (Baltimore)
                Medicine (Baltimore)
                MEDI
                Medicine
                Wolters Kluwer Health
                0025-7974
                1536-5964
                March 2017
                31 March 2017
                : 96
                : 13
                : e6526
                Affiliations
                [a ]Department of Nephrology
                [b ]Department of Respiratory and Critical Care Medicine
                [c ]Department of Laboratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, P.R. China.
                Author notes
                []Correspondence: Lei Chen, Department of Respiratory and Critical Care Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China (e-mail: lchens@ 123456126.com ); Mei Kang, Department of Laboratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China (e-mail: kmeiscu@ 123456126.com ).
                Article
                MD-D-17-00487 06526
                10.1097/MD.0000000000006526
                5380297
                28353613
                ed8a6b9a-c92d-47c2-836e-27fb90fe0269
                Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc.

                This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0

                History
                : 22 January 2017
                : 7 March 2017
                : 9 March 2017
                Categories
                4900
                Research Article
                Clinical Case Report
                Custom metadata
                TRUE

                mass spectroscopy,nocardia otitidiscaviarum,severe pneumonia

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