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Combining trastuzumab and cetuximab combats trastuzumab-resistant gastric cancer by effective inhibition of EGFR/ErbB2 heterodimerization and signaling.
2014-05-31
Animals, Antibodies, Monoclonal, Humanized, administration & dosage, Antineoplastic Combined Chemotherapy Protocols, pharmacology, Apoptosis, drug effects, Blotting, Western, Cell Proliferation, Drug Resistance, Neoplasm, Female, Humans, Immunoprecipitation, Mice, Mice, Inbred BALB C, Protein Multimerization, RNA, Messenger, genetics, Real-Time Polymerase Chain Reaction, Receptor, Epidermal Growth Factor, antagonists & inhibitors, metabolism, Receptor, ErbB-2, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Stomach Neoplasms, drug therapy, pathology, Tumor Cells, Cultured
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Animals,Antibodies, Monoclonal, Humanized,administration & dosage,Antineoplastic Combined Chemotherapy Protocols,pharmacology,Apoptosis,drug effects,Blotting, Western,Cell Proliferation,Drug Resistance, Neoplasm,Female,Humans,Immunoprecipitation,Mice,Mice, Inbred BALB C,Protein Multimerization,RNA, Messenger,genetics,Real-Time Polymerase Chain Reaction,Receptor, Epidermal Growth Factor,antagonists & inhibitors,metabolism,Receptor, ErbB-2,Reverse Transcriptase Polymerase Chain Reaction,Signal Transduction,Stomach Neoplasms,drug therapy,pathology,Tumor Cells, Cultured
Animals, Antibodies, Monoclonal, Humanized, administration & dosage, Antineoplastic Combined Chemotherapy Protocols, pharmacology, Apoptosis, drug effects, Blotting, Western, Cell Proliferation, Drug Resistance, Neoplasm, Female, Humans, Immunoprecipitation, Mice, Mice, Inbred BALB C, Protein Multimerization, RNA, Messenger, genetics, Real-Time Polymerase Chain Reaction, Receptor, Epidermal Growth Factor, antagonists & inhibitors, metabolism, Receptor, ErbB-2, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Stomach Neoplasms, drug therapy, pathology, Tumor Cells, Cultured