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      The impact of musical pleasure and musical hedonia on verbal episodic memory

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          Abstract

          Music listening is one of the most pleasurable activities in our life. As a rewarding stimulus, pleasant music could induce long-term memory improvements for the items encoded in close temporal proximity. In the present study, we behaviourally investigated (1) whether musical pleasure and musical hedonia enhance verbal episodic memory, and (2) whether such enhancement takes place even when the pleasant stimulus is not present during the encoding. Participants (N = 100) were asked to encode words presented in different auditory contexts (highly and lowly pleasant classical music, and control white noise), played before and during (N = 49), or only before (N = 51) the encoding. The Barcelona Music Reward Questionnaire was used to measure participants’ sensitivity to musical reward. 24 h later, participants’ verbal episodic memory was tested (old/new recognition and remember/know paradigm). Results revealed that participants with a high musical reward sensitivity present an increased recollection performance, especially for words encoded in a highly pleasant musical context. Furthermore, this effect persists even when the auditory stimulus is not concurrently present during the encoding of target items. Taken together, these findings suggest that musical pleasure might constitute a helpful encoding context able to drive memory improvements via reward mechanisms.

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          Memory and consciousness.

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            Synaptic tagging and long-term potentiation.

            Repeated stimulation of hippocampal neurons can induce an immediate and prolonged increase in synaptic strength that is called long-term potentiation (LTP)-the primary cellular model of memory in the mammalian brain. An early phase of LTP (lasting less than three hours) can be dissociated from late-phase LTP by using inhibitors of transcription and translation, Because protein synthesis occurs mainly in the cell body, whereas LTP is input-specific, the question arises of how the synapse specificity of late LTP is achieved without elaborate intracellular protein trafficking. We propose that LTP initiates the creation of a short-lasting protein-synthesis-independent 'synaptic tag' at the potentiated synapse which sequesters the relevant protein(s) to establish late LTP. In support of this idea, we now show that weak tetanic stimulation, which ordinarily leads only to early LTP, or repeated tetanization in the presence of protein-synthesis inhibitors, each results in protein-synthesis-dependent late LTP, provided repeated tetanization has already been applied at another input to the same population of neurons. The synaptic tag decays in less than three hours. These findings indicate that the persistence of LTP depends not only on local events during its induction, but also on the prior activity of the neuron.
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              Brain correlates of music-evoked emotions.

              Music is a universal feature of human societies, partly owing to its power to evoke strong emotions and influence moods. During the past decade, the investigation of the neural correlates of music-evoked emotions has been invaluable for the understanding of human emotion. Functional neuroimaging studies on music and emotion show that music can modulate activity in brain structures that are known to be crucially involved in emotion, such as the amygdala, nucleus accumbens, hypothalamus, hippocampus, insula, cingulate cortex and orbitofrontal cortex. The potential of music to modulate activity in these structures has important implications for the use of music in the treatment of psychiatric and neurological disorders.
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                Author and article information

                Contributors
                gcardona.cbpu@gmail.com
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                30 September 2020
                30 September 2020
                2020
                : 10
                : 16113
                Affiliations
                [1 ]GRID grid.5841.8, ISNI 0000 0004 1937 0247, Department of Cognition, Development and Educational Psychology, , University of Barcelona, ; 08035 Barcelona, Spain
                [2 ]GRID grid.417656.7, Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute, , L’Hospitalet de Llobregat, ; 08907 Barcelona, Spain
                [3 ]GRID grid.425902.8, ISNI 0000 0000 9601 989X, Institució Catalana de Recerca i Estudis Avançats, ; 08010 Barcelona, Spain
                [4 ]GRID grid.72960.3a, ISNI 0000 0001 2188 0906, Laboratoire d’Étude des Mécanismes Cognitifs, , Université Lumière Lyon 2, ; 69676 Lyon, France
                Article
                72772
                10.1038/s41598-020-72772-3
                7527554
                32999309
                ecf6d876-314e-4ccd-a11a-8c131e266bd8
                © The Author(s) 2020

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 27 April 2020
                : 26 August 2020
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/100014440, Ministerio de Ciencia, Innovación y Universidades;
                Award ID: PGC2018-099859-B-I00
                Award Recipient :
                Funded by: IMPULSION Grant (IDEX Lyon)
                Categories
                Article
                Custom metadata
                © The Author(s) 2020

                Uncategorized
                cognitive neuroscience,learning and memory,reward
                Uncategorized
                cognitive neuroscience, learning and memory, reward

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