Riluzole–Triazole Hybrids as Novel Chemical Probes for Neuroprotection in Amyotrophic Lateral Sclerosis

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

<p class="first" id="d456794e188"> <div class="figure-container so-text-align-c"> <img alt="" class="figure" src="/document_file/41fb4c8d-0e0b-4a7f-bc9e-da1fc51138e7/PubMedCentral/image/ml-2018-00103y_0004"/> </div> </p><p id="d456794e192">Despite intense attention from biomedical and chemical researchers, there are few approved treatments for amyotrophic lateral sclerosis (ALS), with only riluzole (Rilutek) and edaravone (Radicava) currently available to patients. Moreover, the mechanistic basis of the activity of these drugs is currently not well-defined, limiting the ability to design new medicines for ALS. This Letter describes the synthesis of triazole-containing riluzole analogues, and their testing in a novel neuroprotective assay. Seven compounds were identified as having neuroprotective activity, with two compounds having similar activity to riluzole. </p>

Related collections

Author and article information

Journal

Title: ACS Medicinal Chemistry Letters

Abbreviated Title: ACS Med. Chem. Lett.

Publisher: American Chemical Society (ACS)

ISSN (Print): 1948-5875

ISSN (Electronic): 1948-5875

Publication date Created: May 16 2018

Publication date Created: June 14 2018

Publication date (Electronic): May 30 2018

Publication date (Print): June 14 2018

Volume: 9

Issue: 6

Pages: 552-556

Affiliations

[1 ]Department of Chemistry, Lancaster University, Lancaster LA1 4YB, U.K.

[2 ]School of Pharmacy and Medical Sciences, University of Bradford, Bradford BD7 1DP, U.K.

[3 ]School of Chemistry, Food & Nutritional Sciences and Pharmacy, University of Reading, Reading, Berkshire RG6 6AP, U.K.

[4 ]Department of Chemical Sciences, University of Huddersfield, Huddersfield HD1 3DH, U.K.

Article

DOI: 10.1021/acsmedchemlett.8b00103

PMC ID: 6004570

PubMed ID: 29937981

SO-VID: ecf5a337-73c7-4bd3-b34b-ea20cb1dc348

History

Data availability:

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.