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Melodinines Y 1–Y 4, four monoterpene indole alkaloids from Melodinus henryi†
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22 December 2020
21 December 2020
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Abstract
Melodinines Y 1–Y 4 (1–4), four undescribed alkaloids were isolated from Melodinus henryi. Their structures were elucidated by extensive NMR, mass spectroscopic analyses, theoretical NMR and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of bisindole alkaloids possessing an eburnamine–leuconoxine combination. Compound 3 is a rare 2,3- seco pleiocarpamine type monoterpene indole alkaloid. Compound 1 showed cytotoxic activities against six human cancer cell lines with IC 50 values of 0.5–15.2 μM.
Abstract
Monoterpenoid indole alkaloids from Melodinus henryi
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