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      Guidance for identification and treatment of individuals with attention deficit/hyperactivity disorder and autism spectrum disorder based upon expert consensus

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          Abstract

          Background

          Individuals with co-occurring hyperactivity disorder/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) can have complex presentations that may complicate diagnosis and treatment. There are established guidelines with regard to the identification and treatment of ADHD and ASD as independent conditions. However, ADHD and ASD were not formally recognised diagnostically as co-occurring conditions until the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) was published in 2013. Hence, awareness and understanding of both conditions when they co-occur is less established and there is little guidance in the clinical literature. This has led to uncertainty among healthcare practitioners when working with children, young people and adults who present with co-existing ADHD and ASD. The United Kingdom ADHD Partnership (UKAP) therefore convened a meeting of professional experts that aimed to address this gap and reach expert consensus on the topic that will aid healthcare practitioners and allied professionals when working with this complex and vulnerable population.

          Method

          UK experts from multiple disciplines in the fields of ADHD and ASD convened in London in December 2017. The meeting provided the opportunity to address the complexities of ADHD and ASD as a co-occurring presentation from different perspectives and included presentations, discussion and group work. The authors considered the clinical challenges of working with this complex group of individuals, producing a consensus for a unified approach when working with male and female, children, adolescents and adults with co-occurring ADHD and ASD. This was written up, circulated and endorsed by all authors.

          Results

          The authors reached a consensus of practical recommendations for working across the lifespan with males and females with ADHD and ASD. Consensus was reached on topics of (1) identification and assessment using rating scales, clinical diagnostic interviews and objective supporting assessments; outcomes of assessment, including standards of clinical reporting; (2) non-pharmacological interventions and care management, including psychoeducation, carer interventions/carer training, behavioural/environmental and Cognitive Behavioural Therapy (CBT) approaches; and multi-agency liaison, including educational interventions, career advice, occupational skills and training, and (3) pharmacological treatments.

          Conclusions

          The guidance and practice recommendations (Tables 1, 4, 5, 7, 8 and 10) will support healthcare practitioners and allied professionals to meet the needs of this complex group from a multidisciplinary perspective. Further research is needed to enhance our understanding of the diagnosis, treatment and management of individuals presenting with comorbid ADHD and ASD.

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          Most cited references67

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          The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies.

          This study examined the persistence of attention deficit hyperactivity disorder (ADHD) into adulthood. We analyzed data from published follow-up studies of ADHD. To be included in the analysis, these additional studies had to meet the following criteria: the study included a control group and it was clear from the methods if the diagnosis of ADHD included subjects who did not meet full criteria but showed residual and impairing signs of the disorder. We used a meta-analysis regression model to separately assess the syndromatic and symptomatic persistence of ADHD. When we define only those meeting full criteria for ADHD as having 'persistent ADHD', the rate of persistence is low, approximately 15% at age 25 years. But when we include cases consistent with DSM-IV's definition of ADHD in partial remission, the rate of persistence is much higher, approximately 65%. Our results show that estimates of ADHD's persistence rely heavily on how one defines persistence. Yet, regardless of definition, our analyses show that evidence for ADHD lessens with age. More work is needed to determine if this reflects true remission of ADHD symptoms or is due to the developmental insensitivity of diagnostic criteria for the disorder.
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            Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis.

            In spite of the growing literature about adult attention-deficit hyperactivity disorder (ADHD), relatively little is known about the prevalence and correlates of this disorder. To estimate the prevalence of adult ADHD and to identify its demographic correlates using meta-regression analysis. We used the MEDLINE, PsycLit and EMBASE databases as well as hand-searching to find relevant publications. The pooled prevalence of adult ADHD was 2.5% (95% CI 2.1-3.1). Gender and mean age, interacting with each other, were significantly related to prevalence of ADHD. Meta-regression analysis indicated that the proportion of participants with ADHD decreased with age when men and women were equally represented in the sample. Prevalence of ADHD in adults declines with age in the general population. We think, however, that the unclear validity of DSM-IV diagnostic criteria for this condition can lead to reduced prevalence rates by underestimation of the prevalence of adult ADHD.
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              Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation.

              There is controversy over the nature of the disturbance in brain development that underpins attention-deficit/hyperactivity disorder (ADHD). In particular, it is unclear whether the disorder results from a delay in brain maturation or whether it represents a complete deviation from the template of typical development. Using computational neuroanatomic techniques, we estimated cortical thickness at >40,000 cerebral points from 824 magnetic resonance scans acquired prospectively on 223 children with ADHD and 223 typically developing controls. With this sample size, we could define the growth trajectory of each cortical point, delineating a phase of childhood increase followed by adolescent decrease in cortical thickness (a quadratic growth model). From these trajectories, the age of attaining peak cortical thickness was derived and used as an index of cortical maturation. We found maturation to progress in a similar manner regionally in both children with and without ADHD, with primary sensory areas attaining peak cortical thickness before polymodal, high-order association areas. However, there was a marked delay in ADHD in attaining peak thickness throughout most of the cerebrum: the median age by which 50% of the cortical points attained peak thickness for this group was 10.5 years (SE 0.01), which was significantly later than the median age of 7.5 years (SE 0.02) for typically developing controls (log rank test chi(1)(2) = 5,609, P < 1.0 x 10(-20)). The delay was most prominent in prefrontal regions important for control of cognitive processes including attention and motor planning. Neuroanatomic documentation of a delay in regional cortical maturation in ADHD has not been previously reported.
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                Author and article information

                Contributors
                suzyyoung@aol.com
                Journal
                BMC Med
                BMC Med
                BMC Medicine
                BioMed Central (London )
                1741-7015
                25 May 2020
                25 May 2020
                2020
                : 18
                : 146
                Affiliations
                [1 ]Psychology Services Limited, London, UK
                [2 ]GRID grid.37640.36, ISNI 0000 0000 9439 0839, South London & Maudsley NHS Foundation Trust, Service for Complex Autism and Associated Neurodevelopmental Disorders, ; London, UK
                [3 ]GRID grid.483570.d, ISNI 0000 0004 5345 7223, Department of Children’s Neurosciences, , Evelina London Children’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust, ; London, UK
                [4 ]GRID grid.13097.3c, ISNI 0000 0001 2322 6764, Department of Women & Children’s Health, , King’s College, ; London, UK
                [5 ]Oxford ADHD & Autism Centre, Oxford, UK
                [6 ]CLC Consultancy, Perth, UK
                [7 ]GRID grid.37640.36, ISNI 0000 0000 9439 0839, South London & Maudsley NHS Foundation Trust, National Autism Unit, ; Kent, UK
                [8 ]GRID grid.439572.e, ISNI 0000 0004 0449 9267, Positive Behaviour, Learning Disability, Autism and Mental Health Service (PALMS) Hertfordshire Communication Disorders Clinics, Hertfordshire Community NHS Trust, ; St Albans, UK
                [9 ]South London & Maudsley NHS Foundation Trust, Maudsley Health, Abu Dhabi, UAE
                [10 ]GRID grid.13097.3c, ISNI 0000 0001 2322 6764, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, , King’s College London, ; London, UK
                [11 ]Private Practice, London, UK
                [12 ]GRID grid.420468.c, Great Ormond Street Hospital, ; London, UK
                [13 ]GRID grid.451052.7, ISNI 0000 0004 0581 2008, Behavioural and Developmental Psychiatry Clinical Academic Group, Behavioural Genetics Clinic, National Adult Autism and ADHD Service, , South London and Maudsley Foundation NHS Trust, ; London, UK
                [14 ]GRID grid.13097.3c, ISNI 0000 0001 2322 6764, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, , King’s College London, ; London, UK
                [15 ]GRID grid.466510.0, ISNI 0000 0004 0423 5990, Anna Freud Centre, ; London, UK
                [16 ]Helen Arkell Centre, Guildford, UK
                [17 ]GRID grid.13097.3c, ISNI 0000 0001 2322 6764, Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, , King’s College London, ; London, UK
                [18 ]Diagnostic Assessments and Treatment Services (DATS), Hertfordshire, UK
                [19 ]Stover Consultancy, Santa Barbara, CA USA
                Article
                1585
                10.1186/s12916-020-01585-y
                7247165
                32448170
                ec9dedf3-2382-4089-ba3c-01ed96c1c0da
                © The Author(s) 2020

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 2 August 2019
                : 3 April 2020
                Categories
                Guideline
                Custom metadata
                © The Author(s) 2020

                Medicine
                hyperactivity disorder/hyperactivity disorder (adhd),autism spectrum disorder (asd),comorbidity,assessment,treatment,guidance,consensus,interventions,education,school,occupation,psychiatry,psychology

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