In the present research work, a novel catalyst based on natural material, namely, Fe 3O 4@nano-almondshell@OSi(CH 2) 3/NHCH 2pyridine/Cu II abbreviated (FNAOSiPAMP/Cu II) was designed and prepared. The properties of the catalyst was identified by Fourier-transform infrared spectroscopy (FT-IR), Thermogravimetry ananlysis (TG), X-ray diffraction (XRD), Energy-dispersive X-ray spectroscopy (EDS), Field emission scanning electron microscopy (FESEM), Transmission electron microscopy (TEM), and Mapping. Furthermore, the evaluation of catalytic activity was done in the course of naphtho-1,3-oxazines synthesis. Solvent-free conditions, simplicity of operation, easy work-up and use of an eco-friendly catalyst are some of advantages of this protocol.