The value of platelet-rich plasma in women with previous implantation failure: a systematic review and meta-analysis

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Abstract

Objective

To assess the value of intrauterine PRP to improve IVF outcome in women with previous implantation failure.

Methods

Screening of Pubmed, Web of Science, and other databases from inception to August 2022 using the keywords related to “platelet-rich plasma” OR “PRP” AND “IVF” “implantation failure.” Twenty-nine studies (3308 participants) were included in our analysis, 13 were RCTs, 6 were prospective cohorts, 4 were prospective single arm, and 6 were retrospective analyses. Extracted data included settings of the study, study type, sample size, participants’ characteristics, route, volume, timing of PRP administration, and outcome parameters.

Results

Implantation rate was reported in 6 RCTs (886 participants) and 4 non-RCTs (732 participants). The odds ratio (OR) effect estimate was 2.62 and 2.06, with 95% CI of 1.83, 3.76, and 1.03–4.11, respectively. Endometrial thickness was compared in 4 RCTs (307 participants) and 9 non-RCTs (675 participants), which showed a mean difference of 0.93 and 1.16, with 0.59–1.27 and 0.68–1.65 95% CI, respectively.

Conclusion

PRP administration improves implantation, clinical pregnancy, chemical pregnancy, ongoing pregnancy, live birth rates, and endometrial thickness in women with previous implantation failure.

Supplementary Information

The online version contains supplementary material available at 10.1007/s10815-023-02781-4.

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Most cited references 44

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Mechanisms of implantation: strategies for successful pregnancy.

Jeeyeon Cha, Xiaofei Sun, Sudhansu K Dey (2012)

Physiological and molecular processes initiated during implantation for pregnancy success are complex but highly organized. This review primarily highlights adverse ripple effects arising from defects during the peri-implantation period that perpetuate throughout pregnancy. These defects are reflected in aberrations in embryo spacing, decidualization, placentation and intrauterine embryonic growth, manifesting in preeclampsia, miscarriages and/or preterm birth. Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization.

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The role of growth factors and cytokines during implantation: endocrine and paracrine interactions.

Jeremy S H Taylor, Ozlem Guzeloglu-Kayisli, U Kayisli (2008)

Implantation, a critical step for establishing pregnancy, requires molecular and cellular events resulting in uterine growth and differentiation, blastocyst adhesion, invasion, and placental formation. Successful implantation requires a receptive endometrium, a normal and functional embryo at the blastocyst stage, and a synchronized dialogue between maternal and embryonic tissues. In addition to the well-characterized role of sex steroids, the complexity of embryo implantation and placentation is exemplified by the number of cytokines and growth factors with demonstrated roles in these processes. Disturbances in the normal expression and action of these cytokines result in an absolute or partial failure of implantation and abnormal placental formation in mice and human. Members of the gp130 cytokine family, interleukin-11 (IL-11) and leukemia inhibitory factor, the transforming growth factor beta superfamily, the colony-stimulating factors, and the IL-1 and IL-15 systems are crucial molecules for a successful implantation. Chemokines are also important, both in recruiting specific cohorts of leukocytes to the implantation site and in trophoblast trafficking and differentiation. This review provides discussion of the embryonic and uterine factors that are involved in the process of implantation in autocrine, paracrine, and/or juxtacrine manners at the hormonal, cellular, and molecular levels.

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Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization.

Yajie Chang, Jingjie Li, Yuqing Chen … (2015)

This study was to evaluate the effectiveness of PRP in the therapy of infertile women with thin endometrium (≤ 7 mm).

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Author and article information

Contributors

Ahmed M. Maged:

ORCID: http://orcid.org/0000-0001-7398-474X

prof.ahmedmaged@gmail.com , dr_ahmedmaged@kasralainy.edu.eg , ahmedmaged@cu.edu.eg

Journal

Journal ID (nlm-ta): J Assist Reprod Genet

Journal ID (iso-abbrev): J Assist Reprod Genet

Title: Journal of Assisted Reproduction and Genetics

Publisher: Springer US (New York )

ISSN (Print): 1058-0468

ISSN (Electronic): 1573-7330

Publication date (Electronic): 3 April 2023

Publication date PMC-release: 3 April 2023

Publication date (Print): May 2023

Volume: 40

Issue: 5

Pages: 969-983

Affiliations

[1 ]GRID grid.7776.1, ISNI 0000 0004 0639 9286, Department of Obstetrics and Gynecology, Kasr Al-Ainy Hospital, , Cairo University, ; Cairo, Egypt

[2 ]GRID grid.411662.6, ISNI 0000 0004 0412 4932, Department of Obstetrics and Gynecology, , Beni-Suef University, ; Beni-Suef, Egypt

[3 ]GRID grid.411170.2, ISNI 0000 0004 0412 4537, Department of Obstetrics and Gynecology, , Fayoum University, ; Fayoum, Egypt

Author information

Ahmed M. Maged http://orcid.org/0000-0001-7398-474X

Article

Publisher ID: 2781

DOI: 10.1007/s10815-023-02781-4

PMC ID: 10239431

PubMed ID: 37010710

SO-VID: ebd3edd6-f24d-473f-811d-7f55dd147058

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 18 November 2022

Date accepted : 17 March 2023

Funding

Funded by: Cairo University

Open Access :

Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB).

Custom metadata

ScienceOpen disciplines: Genetics

Keywords: platelet-rich plasma,prp,autologous platelet-rich plasma,implantation failure,thin endometrium

Data availability:

ScienceOpen disciplines: Genetics

Keywords: platelet-rich plasma, prp, autologous platelet-rich plasma, implantation failure, thin endometrium

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The value of platelet-rich plasma in women with previous implantation failure: a systematic review and meta-analysis

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Abstract

Objective

Methods

Results

Conclusion

Supplementary Information

Related collections

Genome Integrity

Most cited references 44

Mechanisms of implantation: strategies for successful pregnancy.

The role of growth factors and cytokines during implantation: endocrine and paracrine interactions.

Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization.

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Contributors

Journal

Affiliations

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Article

History

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Cited by 10

Most referenced authors 389