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Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy.
Hideo Nakanishi
1 ,
Kenji Yamashiro ,
Ryo Yamada ,
Norimoto Gotoh ,
Hisako Hayashi ,
Isao Nakata ,
Masaaki Saito ,
Tomohiro Iida ,
Akio Oishi ,
Yasuo Kurimoto ,
Keitaro Matsuo ,
Kazuo Tajima ,
Fumihiko Matsuda ,
Nagahisa Yoshimura
Dec 2010
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Abstract
To investigate whether the major genetic and environmental risk factors of age-related macular degeneration (AMD)-CFH Y402H and LOC387715 A69S and cigarette smoking-are also associated with polypoidal choroidal vasculopathy (PCV) and whether the associations of CFH Y402H and LOC387715 A69S with PCV are modified by smoking.