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NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis.
Stephen P Gray
1 ,
Elyse Di Marco ,
Jun Okabe ,
Cedric Szyndralewiez ,
Freddy Heitz ,
Augusto C Montezano ,
Judy B de Haan ,
Christine Koulis ,
Assam El-Osta ,
Karen L Andrews ,
Jaye P F Chin-Dusting ,
Rhian M Touyz ,
Kirstin Wingler ,
Mark E Cooper ,
Harald H H W Schmidt ,
Karin A Jandeleit-Dahm
May 07 2013
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Abstract
In diabetes mellitus, vascular complications such as atherosclerosis are a major cause of death. The key underlying pathomechanisms are unclear. However, hyperglycemic oxidative stress derived from NADPH oxidase (Nox), the only known dedicated enzyme to generate reactive oxygen species appears to play a role. Here we identify the Nox1 isoform as playing a key and pharmacologically targetable role in the accelerated development of diabetic atherosclerosis.