- Record: found
- Abstract: not found
- Article: not found
Genetic variability following selection of Haemonchus contortus with anthelmintics
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Genetic diversity in nematodes leads to variation in response to anthelmintics. Haemonchus
contortus shows enormous genetic diversity, allowing anthelmintic resistance alleles
to be rapidly selected. Anthelmintic resistance is now a widespread problem, especially
in H. contortus. Here, I compare the genes involved in anthelmintic resistance in
H. contortus with those that confer susceptibility or resistance on the free living
nematode Caenorhabditis elegans. I also discuss the latest knowledge of genes associated
with resistance to benzimidazoles, levamisole and the macrocyclic lactones and the
need for DNA markers for anthelmintic resistance.