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      Bone damage and health-related quality of life in Hodgkin lymphoma survivors: closing the gaps

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          Abstract

          In the recent decades, remarkable successes have been recorded in the treatment of Hodgkin’s lymphoma to the point that today it represents one of the neoplasms with the highest rates of cure and with the highest life expectancy. Nonetheless, this raises the concern for the health of long- term survivors. Late side effects of treatments in synergy with other risk factors expose survivors to increased morbidity and impaired quality of life. In the complexity of the topics concerning these last aspects, an area of growing interest is that of bone damage that follows Hodgkin Lymphoma and its treatments. In this narrative review, we conducted our work through assessment of available evidence focusing on several aspects linking bone damage and quality of life with Hodgkin lymphoma and its treatments. At present, the problem of osteopenia and osteoporosis in Hodgkin lymphoma survivors is a theme for which awareness and knowledge need to be implemented.

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          Most cited references106

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          Sarcopenia: revised European consensus on definition and diagnosis

          doi: 10.1093/ageing/afy169 In the original version of the above paper there was an error in Table 3, which shows the recommended cut-off points for ASM/height2 in women. The cut-off point was given as <6.0 kg/m2, but the correct value is <5.5 kg/m2. This has now been corrected online. The authors wish to apologise for this error.
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            Pathological pain and the neuroimmune interface.

            Reciprocal signalling between immunocompetent cells in the central nervous system (CNS) has emerged as a key phenomenon underpinning pathological and chronic pain mechanisms. Neuronal excitability can be powerfully enhanced both by classical neurotransmitters derived from neurons, and by immune mediators released from CNS-resident microglia and astrocytes, and from infiltrating cells such as T cells. In this Review, we discuss the current understanding of the contribution of central immune mechanisms to pathological pain, and how the heterogeneous immune functions of different cells in the CNS could be harnessed to develop new therapeutics for pain control. Given the prevalence of chronic pain and the incomplete efficacy of current drugs--which focus on suppressing aberrant neuronal activity--new strategies to manipulate neuroimmune pain transmission hold considerable promise.
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              The diagnosis of osteoporosis.

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                Author and article information

                Contributors
                Journal
                Front Oncol
                Front Oncol
                Front. Oncol.
                Frontiers in Oncology
                Frontiers Media S.A.
                2234-943X
                09 February 2024
                2024
                : 14
                : 1201595
                Affiliations
                [1] Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Division of Hematology, University of Palermo , Palermo, Italy
                Author notes

                Edited by: Esther Natalie Oliva, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Italy

                Reviewed by: Hussain Alizadeh, University of Pécs, Hungary

                Arlette Setiawan, Padjadjaran University, Indonesia

                *Correspondence: Salvatrice Mancuso, salvatrice.mancuso@ 123456unipa.it
                Article
                10.3389/fonc.2024.1201595
                10884223
                e9bc774f-0c9c-447a-ba24-d524f6093fd6
                Copyright © 2024 Mancuso, Mattana, Giammancheri, Russello, Carlisi, Santoro and Siragusa

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 06 April 2023
                : 16 January 2024
                Page count
                Figures: 1, Tables: 1, Equations: 0, References: 106, Pages: 10, Words: 5587
                Funding
                The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The study was partially sustained by FFR funds.
                Categories
                Oncology
                Review
                Custom metadata
                Hematologic Malignancies

                Oncology & Radiotherapy
                hodgkin lymphoma,hodgkin lymphoma survivors,osteoporosis,bone loss,quality of life,osteosarcopenia,ageing,frailty hodgkin lymphoma

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