Nasal Nitric Oxide Measurement in Primary Ciliary Dyskinesia. A Technical Paper on Standardized Testing Protocols

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Nasal nitric oxide concentrations are extremely low in primary ciliary dyskinesia (PCD), and measurement of this nasal gas is recommended as a PCD diagnostic test in cooperative patients aged 5 years and older. However, nasal nitric oxide measurements must be performed with chemiluminescence analyzers using a standardized protocol to ensure proper results, because nasal nitric oxide values can be influenced by various internal and external factors. Repeat nasal nitric oxide testing on separate visits is required to ensure that low diagnostic values are persistent and consistent with PCD. This technical paper presents the standard operating procedures for nasal nitric oxide measurement used by the PCD Foundation Clinical and Research Centers Network at various specialty centers across North America. Adherence to this document ensures reliable nasal nitric oxide testing and high diagnostic accuracy when employed in a population with appropriate clinical phenotypes for PCD.

Related collections

Author and article information

Journal

Journal ID (nlm-ta): Ann Am Thorac Soc

Journal ID (iso-abbrev): Ann Am Thorac Soc

Journal ID (publisher-id): AnnalsATS

Title: Annals of the American Thoracic Society

Publisher: American Thoracic Society

ISSN (Print): 2329-6933

ISSN (Electronic): 2325-6621

Publication date (Print and electronic): February 2020

Publication date (Print): February 2020

Volume: 17

Issue: 2

Pages: e1-e12

Affiliations

[ ¹ ]Division of Pediatric Respiratory Medicine, McGill University Health Centre Research Institute, Montreal Children’s Hospital, Montreal, Quebec, Canada

[ ² ]Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

[ ³ ]Children’s Lung Foundation Professor of Pediatrics, Rainbow Babies and Children’s Hospital, Cleveland, Ohio

[ ⁴ ]Division of Pediatric Pulmonary, Allergy, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee

[ ⁵ ]Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio

[ ⁶ ]PCD Foundation, Minneapolis, Minnesota

[ ⁷ ]Department of Medicine

[ ⁸ ]Center for Environmental Medicine, Asthma and Lung Biology

[ ⁹ ]Department of Pediatrics, and

[ ¹⁰ ]Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina

Author notes

Correspondence and requests for reprints should be addressed to Adam J. Shapiro, M.D., Research Institute, McGill University Health Centre, Montreal Children’s Hospital, 1001 Decarie Boulevard, BRC.5016, Montreal, PQ, H4A 3J1 Canada. E-mail: adam.shapiro@ 123456muhc.mcgill.ca .

[*]

S.D.D. is Deputy Editor of AnnalsATS. Her participation complies with American Thoracic Society requirements for recusal from review and decisions for authored works.

Author information

Adam J. Shapiro http://orcid.org/0000-0001-6066-6750

Sharon D. Dell http://orcid.org/0000-0003-2169-9407

Article

Accession ID: PMC6993796 Pmcid ID: PMC6993796 Pmc-uid ID: 6993796 Publisher-manuscript ID: 201904-347OT

DOI: 10.1513/AnnalsATS.201904-347OT

PMC ID: 6993796

PubMed ID: 31770003

SO-VID: e9a1d2ef-da38-49b4-a993-9bfbdb16b0cb

History

Date received : 30 April 2019

Date accepted : 26 November 2019

Page count

Figures: 9, Tables: 2, Pages: 12

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Cited by 25

See all cited by

- Version 1