The current work involves synthesis of hybrid nanomaterial of In 2O 3/MoS 2/Fe 3O 4 and their applications as photocatalysts for disintegration of esomeprazole under visible light illumination. The data emerged from various analyses testified to the successful construction of the desired nano-scaled hybrid photocatalyst. Tauc plot gave the band gap of In 2O 3/MoS 2/Fe 3O 4 to be ~ 2.15 eV. Synergistic effects of the integrant components enabled efficacious photocatalytic performances of the nanocomposite. The nanohybrid photocatalyst In 2O 3/MoS 2/Fe 3O 4 showed photodecomposition up to ~ 92.92% within 50 min. The current work realizes its objective of constructing metal oxide based hybrid nano-photocatalyst supported on MoS 2 sheets for activity in the visible spectrum, which displayed remarkable capacity of disintegrating emerging persistent organic contaminants and are magnetically recoverable.