Ocular Demodicosis as a Potential Cause of Ocular Surface Inflammation :

Abstract

<p class="first" id="P1">Among different species of mites, <i>Demodex folliculorum</i> and <i>Demodex brevis</i> are the only two that affect the human eye. Because demodicosis is highly age-dependent and can be found in asymptomatic adults, the pathogenicity of these mites has long been debated. Herein, we summarize our research experience including our most recent study regarding <i>Demodex</i> infestation as a potential cause of ocular inflammatory diseases. Specifically, we describe the pathogenesis of demodicosis and then discuss the results of work investigating the associations and relationships between ocular demodicosis and blepharitis, meibomian gland diseases, and keratitis, in turn. This is followed by some discussion of the diagnosis of demodicosis, and concludes with a brief discussion of the evidence for different treatments for ocular demodicosis. Collectively, our studies suggest a strong correlation between ocular demodicosis and ocular surface inflammatory conditions, such as blepharitis, chalazia, MGD, and keratitis. Further investigation of the underlying pathogenic mechanism is warranted. </p>