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      Suppressing phosphoinositide-specific phospholipases Cγ1 promotes mineralization of osteoarthritic subchondral bone osteoblasts via increasing autophagy, thereby ameliorating articular cartilage degeneration.

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          Abstract

          Phosphoinositide-specific phospholipases C-γ1 (PLC-γ1) signaling has been shown to modulate osteoarthritis (OA) chondrocyte metabolism. However, the role of PLC-γ1 in OA osteoblasts remains unclear. Herein, whether and how PLC-γ1 was involved in mineralization in OA subchondral bone osteoblasts were investigated.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Bone
          Title: Bone
          Publisher:
          ISSN (Electronic): 1873-2763
          ISSN (Print): 1873-2763
          Publication date (Electronic): Jan 2022
          Volume: 154
          Affiliations
          [1 ] Bone & Joint Research Institute, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
          [2 ] School of Medicine, Xiamen University, Xiamen, Fujian, China.
          [3 ] School of Medicine, Xiamen University, Xiamen, Fujian, China. Electronic address: cristal66@xmu.edu.cn.
          [4 ] Bone & Joint Research Institute, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China. Electronic address: chunxia@xmu.edu.cn.
          Article
          Publisher Item ID: S8756-3282(21)00428-2
          DOI: 10.1016/j.bone.2021.116262
          PubMed ID: 34813965
          SO-VID: e8dcc87b-4ce6-4cb0-ae4d-da0a8d16c414
          History

          Keywords: Osteoarthritis subchondral bone osteoblasts,PLC-γ1 signaling,Mineralization,Endoplasmic reticulum stress,Autophagy,Articular cartilage degeneration
          Data availability:
          Keywords: Osteoarthritis subchondral bone osteoblasts, PLC-γ1 signaling, Mineralization, Endoplasmic reticulum stress, Autophagy, Articular cartilage degeneration

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