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      Exploitation of polyphenols and proteins using nanoencapsulation for anti-viral and brain boosting properties – Evoking a synergistic strategy to combat COVID-19 pandemic

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          Abstract

          The world is currently under the threat of COVID pandemic and has focused every dimension of research in finding a cure to this novel disease. In this current situation, people are facing mental stress, agony, fear, depression and other associated symptoms which are taking a toll on their overall mental health. Nanoencapsulation of certain brain boosting polyphenols including quercetin, caffeine, cocoa flavanols and proteins like lectins can become new area of interest in the present scenario. Besides the brain boosting benefits, we have also highlighted the anti- viral activities of these compounds which we assume can play a possible role in combating COVID-19 given to their previous history of action against certain viruses. This review outlines the nanoencapsulation approaches of such synergistic compounds as a novel strategy to take the ongoing research a step ahead and also provides a new insight in bringing the role of nanotechnology in addressing the issues related to COVID pandemic.

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          Most cited references117

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          Nanocarriers as an emerging platform for cancer therapy.

          Nanotechnology has the potential to revolutionize cancer diagnosis and therapy. Advances in protein engineering and materials science have contributed to novel nanoscale targeting approaches that may bring new hope to cancer patients. Several therapeutic nanocarriers have been approved for clinical use. However, to date, there are only a few clinically approved nanocarriers that incorporate molecules to selectively bind and target cancer cells. This review examines some of the approved formulations and discusses the challenges in translating basic research to the clinic. We detail the arsenal of nanocarriers and molecules available for selective tumour targeting, and emphasize the challenges in cancer treatment.
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            Study of knowledge, attitude, anxiety & perceived mental healthcare need in Indian population during COVID-19 pandemic

            Highlights • There is moderate awareness related to transmission and symptoms of COVID-19 among educated population in India. • There is adequate awareness among public regarding preventive measures for COVID-19 infection. • There is a positive attitude of public towards social-distancing, avoiding party and travel and maintaining hygiene. • People report anxiety, worries, paranoia about acquiring infection and sleep disturbances during this pandemic. • More the 80 % people perceive mental healthcare need to deal with their issues during this COVID-19 pandemic.
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              Potential interventions for novel coronavirus in China: A systematic review

              Abstract An outbreak of a novel coronavirus (COVID‐19 or 2019‐CoV) infection has posed significant threats to international health and the economy. In the absence of treatment for this virus, there is an urgent need to find alternative methods to control the spread of disease. Here, we have conducted an online search for all treatment options related to coronavirus infections as well as some RNA‐virus infection and we have found that general treatments, coronavirus‐specific treatments, and antiviral treatments should be useful in fighting COVID‐19. We suggest that the nutritional status of each infected patient should be evaluated before the administration of general treatments and the current children's RNA‐virus vaccines including influenza vaccine should be immunized for uninfected people and health care workers. In addition, convalescent plasma should be given to COVID‐19 patients if it is available. In conclusion, we suggest that all the potential interventions be implemented to control the emerging COVID‐19 if the infection is uncontrollable.
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                Author and article information

                Journal
                Int J Biol Macromol
                Int J Biol Macromol
                International Journal of Biological Macromolecules
                Published by Elsevier B.V.
                0141-8130
                1879-0003
                11 March 2021
                11 March 2021
                Affiliations
                [a ]Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India
                [b ]Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, United States
                [c ]Department of Food Technology, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
                Author notes
                [* ]Corresponding author at: Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India.
                Article
                S0141-8130(21)00545-6
                10.1016/j.ijbiomac.2021.03.028
                7946821
                e89859e0-5f27-4b38-ab23-aeb3ef4946a7
                © 2021 Published by Elsevier B.V.

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                : 29 October 2020
                : 31 January 2021
                : 4 March 2021
                Categories
                Review

                Biochemistry
                lectins,caffeine,cocoa flavonoids,nanoencapsulation,quercetin
                Biochemistry
                lectins, caffeine, cocoa flavonoids, nanoencapsulation, quercetin

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