12
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The total synthesis of a ganglioside Hp-s1 analogue possessing neuritogenic activity by chemoselective activation glycosylation.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The total synthesis of ganglioside 2, an analogue of the ganglioside Hp-s1 (1) which displays neuritogenic activity toward the rat pheochromocytoma cell line PC-12 cell in the presence of nerve growth factor (NGF) with an effect (34.0%) greater than that of the mammalian ganglioside GM 1 (25.4%), was accomplished by applying a chemoselective-activation glycosylation strategy. Moreover, we also demonstrate that the synthesized ganglioside 2 exhibited neuritogenic activity toward the human neuroblastoma cell line SH-SY5Y without the presence of NGF.

          Related collections

          Author and article information

          Journal
          Org. Biomol. Chem.
          Organic & biomolecular chemistry
          Royal Society of Chemistry (RSC)
          1477-0539
          1477-0520
          Feb 07 2012
          : 10
          : 5
          Affiliations
          [1 ] Department of Chemistry, Chung Yuan Christian University, Chung Li 32023, Taiwan. tsaiyofu@cycu.edu.tw
          Article
          10.1039/c2ob06827c
          22179062
          e886469e-1dba-4f31-892e-efed10758f18
          History

          Comments

          Comment on this article

          scite_
          26
          1
          30
          0
          Smart Citations
          26
          1
          30
          0
          Citing PublicationsSupportingMentioningContrasting
          View Citations

          See how this article has been cited at scite.ai

          scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

          Similar content417

          Cited by6